Evidence map›Paper›PMID 42244972›Full record

ArticleTheranostics2026

A dual functional theranostic microneedle patch for immunomodulation and real time monitoring in diabetic wound therapy.

Shuai Fan, Junlong Zhong, Yeke Chen, Kang Chen, Zhiming Liu, Xinmin Yang, Wen Tan, Wenlong Tang, Wanhui Zhou, Degui Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shuai FanOrthopedic Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330209, China.
Junlong ZhongOrthopedic Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330209, China.
Yeke ChenBio 3D Printing Laboratory, School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 330031, China.
Kang ChenDepartment of Orthopedics, Affiliated Rehabilitation Hospital of Nanchang University, Jiangxi 330003, China.
Zhiming LiuOrthopedic Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330209, China.
Xinmin YangDepartment of Orthopedics, Affiliated Rehabilitation Hospital of Nanchang University, Jiangxi 330003, China.
Wen TanDepartment of Orthopedics, Affiliated Rehabilitation Hospital of Nanchang University, Jiangxi 330003, China.
Wenlong TangBio 3D Printing Laboratory, School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 330031, China.
Wanhui ZhouBio 3D Printing Laboratory, School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 330031, China.
Degui WuBio 3D Printing Laboratory, School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 330031, China.
Jiachao XiongOrthopedic Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330209, China.
Zhenhai ZhouOrthopedic Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330209, China.
Fanrong AiBio 3D Printing Laboratory, School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 330031, China.
Kai CaoThe Key Laboratory of Spine and Spinal Cord Disease of Jiangxi Province, Nanchang, Jiangxi 330006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: The management of diabetic wound is limited by the absence of delivery systems that can dynamically respond to the complex pathological microenvironment. Herein, we have engineered a dual-functional theranostic microneedle (MN) patch for intelligent diabetic wound therapy. Methods: The patch (termed MNs@Z/CP) features a spatially designed bilayer architecture: the needle tips are loaded with a catalytic nanozyme (ZTCG) for on-demand therapy, exhibiting cascade superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities to simultaneously alleviate oxidative stress and hypoxia while combating bacterial infection; the backing layer incorporates a cerium metal-organic framework (Ce-MOF)-based visual sensor for real-time monitoring of wound H Results: MNs@Z/CP not only exhibited multimodal antibacterial and anti-inflammatory effects but also reprogrammed the immune microenvironment by activating the Nrf2/HO-1 pathway to shift macrophages from a pro-inflammatory (M1) to a pro-healing (M2) phenotype. In both diabetic and methicillin-resistant Conclusion: This work pioneers a theranostic platform that integrates real-time diagnostic, controlled catalytic therapy, and immunomodulatory therapy, providing a viable approach to the autonomous management of chronic wounds.

Indexed as

Diabetes ComplicationsTheranostic NanomedicineWound HealingAnimalsAnti-Bacterial AgentsDiabetes Mellitus, ExperimentalDisease Models, AnimalHumansHydrogen PeroxideImmunomodulationMaleMethicillin-Resistant Staphylococcus aureusMiceMicroneedle Drug DeliveryStaphylococcal InfectionsAnti-Bacterial AgentsHydrogen Peroxidediabetic wound healingmacrophage reprogrammingmetal-organic frameworksmicroneedle patches

Identifiers

PMID42244972
PMCPMC13231991

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.