ArticleBrain communications2026
Sleep increases firing rate modulation during interictal epileptiform discharges in mesial temporal structures.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Multistage sleep recordings: a missing piece in the puzzle of human interictal single-neuron dynamics.Brain communications · 2026Article
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8 authors.
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Abstract
Epileptic seizures and interictal epileptiform discharges are strongly influenced by sleep and circadian rhythms. However, human data on the effect of sleep on neuronal behaviour during interictal activity have been lacking. We analysed EEG from eight epileptic patients implanted with macro and micro electrodes in mesial temporal structures. Sleep staging was performed on polysomnography and video-EEG. Automated detection identified thousands of interictal epileptiform discharges per patient. Both their rate and amplitude increased with deeper stages of non-rapid eye movement sleep. Single- and multi-unit firing rates were often temporally coupled with local field potentials, exhibiting increased firing during the spike and decreased activity during the following slow wave. These time-locked firing rate modulations were shown to increase during deeper stages of non-rapid eye movement sleep. Furthermore, neuronal background activity showed a decrease in firing rate, bursting and regularity with deeper stages of non-rapid eye movement sleep.
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