ReviewInternational journal of chronic obstructive pulmonary disease2026
The Role of Microbiota Homeostasis in the Progression and Treatment of Chronic Obstructive Pulmonary Disease.
Review in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous chronic respiratory disorder characterized by persistent airflow obstruction. Its high morbidity and mortality have posed a substantial public health burden, with current symptomatic treatments exhibiting inadequate control and potential adverse effects. With advances in microecological research techniques, the critical role of microbial homeostasis in the oral cavity, lungs, and gut in respiratory health has become increasingly prominent, and microbial dysbiosis is closely associated with progression and therapeutic outcomes of COPD. This review summarizes the compositional alterations of oral, lung, and gut microbiota in COPD patients, analyzes the interactions of the oral-lung axis and gut-lung axis, and delineates three mechanisms through which microbial dysbiosis promotes COPD progression: pathogenic bacterial migration, abnormal metabolite production and immune dysregulation. Additionally, this review summarizes Western and traditional Chinese medicine interventions targeting microbiota homeostasis, including antibiotics, microecological preparations, and herbal medicines, which have shown potential in improving COPD clinical outcomes. This review aims to provide a theoretical reference for the clinical diagnosis and management of COPD.
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