ArticleFrontiers in pharmacology2026
A study on the treatment of enamel white spot lesions using chitosan-calcium phosphate microgels loaded with EGCG-NPs.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: During orthodontic treatment, fixed orthodontic appliances complicate optimal oral hygiene maintenance, frequently causing white spot lesions (WSLs). Clinically, WSLs are typical chalky-white opacities on the enamel surface, recognized as the early reversible stage of dental caries. In this study, a novel antibacterial and remineralizing material-CEN composites (Chitosan-Ca Methods: Material characterization experiments were conducted on EGCG-NPs, chitosan-calcium phosphate microgels and CEN composites; the dialysis bag diffusion method was used to determine the composite drug release rate. Enamel blocks were prepared, an acid-etched demineralization model was established, and Conclusion: Material characterization experiments confirmed the successful synthesis of CEN composites. Drug release tests showed EGCG-NPs release rate reached 50% at 10 h and 80% at 70 h.
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