Evidence map›Paper›PMID 42244760›Full record

ArticlebioRxiv : the preprint server for biology2026

Amino Acids in the RSSY Motif of Lipoyl Synthase Control Substrate Binding and Reactivity

Vivian Robert Jeyachandran, Nicholas D Lanz, Maria-Eirini Pandelia, Justin M Rectenwald, Jay V Pendyala, Ravi K Maurya, Amie K Boal, Carsten Krebs, Squire J Booker

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vivian Robert JeyachandranDepartment of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-7987-4346
Nicholas D LanzDepartment of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-8717-3523
Maria-Eirini PandeliaDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-6750-1948
Justin M RectenwaldDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0003-2212-6301
Jay V PendyalaDepartment of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0003-4288-6439
Ravi K MauryaDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0009-0001-5387-7995
Amie K BoalDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-1234-8472
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-3302-7053
Squire J BookerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.ORCID 0000-0002-7211-5937

Funding

Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0M
Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
Radical Mechanisms of Iron-Sulfur ProteinsR35GM122595 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SQUIRE J. BOOKER · 2017 to 2026
$3.4M
From humans and eukaryotes to viruses and pathogens; how transition metals shape catalysis and allosteryR35GM156452 · NIGMS · BRANDEIS UNIVERSITY · PI Maria-Eirini Pandelia · 2025 to 2026
$935k
NIGMS NIH HHS R35 GM119707NIGMS NIH HHS R35 GM122595NIGMS NIH HHS R35 GM127079NIGMS NIH HHS R35 GM156452
6 · The paper itself

Abstract

The last step in the biosynthesis of the lipoyl cofactor (LipCo) is the addition of two sulfur atoms at C6 and C8 of an

Indexed as

Iron-sulfur clusterlipoic acidlipoyl synthaseNfuAradical SAM enzymeRSSY motifserine ligand

Identifiers

PMID42244760
PMCPMC13232139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.