Evidence map›Paper›PMID 42244754›Full record

ArticlebioRxiv : the preprint server for biology2026

Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8

Benjamin Ds Clarkson, Susanna Pucci, Ramila Barun Shrestha, Kiran K Mangalaparthi, Remya Raja, Marion Curtis, Akhilesh Pandey, Charles L Howe

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Benjamin Ds ClarksonTranslational Neuroimmunology Laboratory, Mayo Clinic, Rochester, Minnesota, USA.
Susanna PucciTranslational Neuroimmunology Laboratory, Mayo Clinic, Rochester, Minnesota, USA.
Ramila Barun ShresthaTranslational Neuroimmunology Laboratory, Mayo Clinic, Rochester, Minnesota, USA.
Kiran K MangalaparthiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Remya RajaDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, USA.
Marion CurtisDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Charles L HoweTranslational Neuroimmunology Laboratory, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-3889-8739

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Mayo Clinic Center for Clinical ProteomicsU01CA271410 · NCI · MAYO CLINIC ROCHESTER · PI Rafael Fonseca, AKHILESH PANDEY · 2022 to 2026
$5.3M
Mechanisms of neuronal injury during virus infection of the CNSR01NS064571 · NINDS · MAYO CLINIC ROCHESTER · PI HOWE, CHARLES LEE · 2009 to 2018
$3.0M
NCI NIH HHS P30 CA015083NCI NIH HHS U01 CA271410NINDS NIH HHS R01 NS064571
6 · The paper itself

Abstract

Interferon-γ (IFNγ) signaling is prominent in inflammatory CNS microenvironments across many neurological disorders, but the neuronal peptides presented on HLA class I under these conditions and their functional consequences for CD8

Indexed as

antigen presentationCD8+ T cellsHLA class Iimmunopeptidomicsinduced pluripotent stem cellsInterferon-γ (IFNγ)neural organoidneuroinflammation

Identifiers

PMID42244754
PMCPMC13232320

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.