Evidence map›Paper›PMID 42244746›Full record

ArticlebioRxiv : the preprint server for biology2026

A microRNA atlas of the human prefrontal cortex across the adult lifespan.

Irais Erendira Valenzuela-Arzeta, Pourya Naderi Yeganeh, Anupama Rai, Jane Banahan, Artemis Iatrou, Leinal Sejour, Madison Uyemura, Isaac H Solomon, Nikolaos P Daskalakis, Ioannis Vlachos and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Irais Erendira Valenzuela-ArzetaDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-7657-5316
Pourya Naderi YeganehDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-4693-8331
Anupama RaiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jane BanahanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Artemis IatrouDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.ORCID 0000-0001-9866-5497
Leinal SejourPrecision RNA Medicine Core, Bioinformatics Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Madison UyemuraDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Isaac H SolomonDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Nikolaos P DaskalakisDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.ORCID 0000-0003-1660-9112
Ioannis VlachosDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-8849-808X
Winston HideDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-8621-3271
Frank J SlackDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-8263-0409
Maria MavrikakiDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-8646-5022

Funding

Non-coding RNAs in resilience to Alzheimer’s DiseaseR01AG082093 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Winston Alexander Hide, Doo Yeon Kim · 2023 to 2026
$3.4M
Molecular mechanisms of aging and accelerated aging in the human brainR01AG079799 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Maria Mavrikaki · 2023 to 2026
$2.7M
Juvenile microRNAs promoting healthier adult agingR01AG058816 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SLACK, FRANK J. · 2018 to 2022
$1.9M
NIA NIH HHS R01 AG058816NIA NIH HHS R01 AG079799NIA NIH HHS R01 AG082093
6 · The paper itself

Abstract

Aging of the human brain is characterized by widespread changes in gene expression regulated in part by microRNAs (miRNAs). We present a lifespan miRNA atlas of the human dorsolateral prefrontal cortex generated from small RNA sequencing of 113 postmortem samples spanning 18 to 100 years of age. Differential expression analysis revealed progressive age-associated remodeling of miRNA expression, with the strongest differences observed between old and young individuals. Among the significantly altered miRNAs, miR-34a-5p emerged as one of the most robustly upregulated miRNAs in the aged cortex, alongside additional aging-associated miRNAs including miR-155-5p, miR-132-3p, miR-212-3p, miR-449a, and members of the miR-302 family. This atlas provides a resource for investigating miRNA dysregulation and small RNA regulatory networks during human cortical aging.

Identifiers

PMID42244746
PMCPMC13232148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.