Evidence map›Paper›PMID 42244695›Full record

ArticlebioRxiv : the preprint server for biology2026

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma.

Jasper Hsu, Hyemin Song, Satoshi Ogawa, Casie S Kubota, Kristina L Peck, Emily Jacobs, Lizmarie Garcia-Rivera, Jonathan Zhu, Yuan Sui, Woncheol Jung and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jasper HsuSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0001-8576-1957
Hyemin SongSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0002-3660-5904
Satoshi OgawaSalk Institute for Biological Studies, La Jolla, California, USA.
Casie S KubotaSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0003-2323-7409
Kristina L PeckSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0009-0004-7235-2774
Emily JacobsSalk Institute for Biological Studies, La Jolla, California, USA.
Lizmarie Garcia-RiveraSalk Institute for Biological Studies, La Jolla, California, USA.
Jonathan ZhuSalk Institute for Biological Studies, La Jolla, California, USA.
Yuan SuiSalk Institute for Biological Studies, La Jolla, California, USA.
Woncheol JungUniversity of Oklahoma, College of Medicine, Oklahoma City, Oklahoma, USA.
Yang DaiSalk Institute for Biological Studies, La Jolla, California, USA.
Jan LumibaoSalk Institute for Biological Studies, La Jolla, California, USA.
Chelsea R BottomleySalk Institute for Biological Studies, La Jolla, California, USA.
Kassidy CurtisSalk Institute for Biological Studies, La Jolla, California, USA.
Mars BauSalk Institute for Biological Studies, La Jolla, California, USA.
Ellyse KuSalk Institute for Biological Studies, La Jolla, California, USA.
Kahing KuoSalk Institute for Biological Studies, La Jolla, California, USA.
Araceli Herrera MoralesSalk Institute for Biological Studies, La Jolla, California, USA.
McKenna StampSalk Institute for Biological Studies, La Jolla, California, USA.
Angelica RockSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0009-0007-3360-1709
Shira R OkhovatSalk Institute for Biological Studies, La Jolla, California, USA.
Tony HunterSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0002-7691-6993
Michael DownesSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0002-6351-9585
Ronald EvansSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0002-9986-5965
Jingjing ZouDepartment of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of California San Diego, San Diego, California, USA.ORCID 0000-0002-4749-105X
Tae Gyu OhUniversity of Oklahoma, College of Medicine, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-2756-3546
Ye ZhengSalk Institute for Biological Studies, La Jolla, California, USA.
Andrew M LowyDepartment of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of California San Diego, San Diego, California, USA.ORCID 0000-0002-7106-0735
Herve TiriacDepartment of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of California San Diego, San Diego, California, USA.ORCID 0000-0001-5039-6750
Susan M KaechSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0003-1674-1420
Dannielle D EngleSalk Institute for Biological Studies, La Jolla, California, USA.ORCID 0000-0003-1876-7675

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
Project 3: The AMPK Autophagy Pathway as a Metabolic Liability in Pancratic Ductal AdenocarcinomaP01CA265762 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Susan M Kaech · 2023 to 2026
$14.6M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Salk Institute Cancer Training GrantT32CA009370 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Diana Clare Hargreaves, Jan Karlseder · 1986 to 2026
$8.6M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
The effect of cancer cell produced collagen 1 homotrimers on DDR1 signaling activation by microenvironmental collagen 1 fragments.U01CA274295 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin, ANDREW M LOWY · 2022 to 2026
$5.2M
The role of BAF related complexes in regulatory T cell development and functionR01AI151123 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, ZHENG, YE · 2020 to 2024
$4.0M
Spectral Configured Bigfoot Sorter for Salk Institute Flow Cytometry CoreS10OD034268 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'CONNOR, CAROLYN PEY-MIN · 2023 to 2023
$724k
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
Investigating the Role of Fibulin 3 in Pancreatic TumorigenesisF31CA294995 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Hyemin Song · 2025 to 2026
$93k
NCI NIH HHS F31 CA294995NCI NIH HHS P01 CA265762NCI NIH HHS P30 CA014195NCI NIH HHS T32 CA009370NCI NIH HHS U01 CA274295NIAID NIH HHS R01 AI151123NIA NIH HHS P30 AG068635NIGMS NIH HHS T32 GM133351NIH HHS S10 OD023689NIH HHS S10 OD034268
6 · The paper itself

Abstract

Durable therapeutic efficacy remains a major barrier to improving outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). An immunosuppressive tumor microenvironment (TME) is a hallmark of PDAC and has been demonstrated to be a dominant driver of therapeutic resistance. The aberrant glycan CA19-9 is prevalent in PDAC and drives tumor progression, but the paracrine mechanisms by which it contributes to TME remodeling are unknown. To address this, we mapped TME changes and performed functional analyses using a genetically engineered mouse model (GEMM) harboring Kras

Identifiers

PMID42244695
PMCPMC13232252

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.