Evidence map›Paper›PMID 42244664›Full record

ArticlebioRxiv : the preprint server for biology2026

An ancient retrotransposon provides species-specific tuning of IL-18 inflammatory signaling.

Andrea D Ordonez, Holly Allen, Lynn Sanford, Atma Ivancevic, Ashley Agyepong, Mia Chaw, James P Bridges, Tony Schountz, Edward B Chuong

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea D OrdonezBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0000-0002-0007-5673
Holly AllenBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0000-0002-7014-1349
Lynn SanfordBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0000-0002-1255-556X
Atma IvancevicBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0000-0002-0101-9876
Ashley AgyepongBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0009-0006-5651-1071
Mia ChawBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0009-0002-6464-0544
James P BridgesDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO. 80206, USA.ORCID 0000-0002-4815-117X
Tony SchountzDepartment of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO. 80523, USA.ORCID 0000-0002-1292-7650
Edward B ChuongBioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO. 80309, USA.ORCID 0000-0002-5392-937X

Funding

Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Transposon-mediated rewiring of gene regulatory networksR35GM128822 · NIGMS · UNIVERSITY OF COLORADO · PI Edward Bo-yi Chuong · 2018 to 2026
$3.5M
NIGMS NIH HHS R35 GM128822NIGMS NIH HHS T32 GM142607
6 · The paper itself

Abstract

Species differ markedly in how they regulate immune responses, yet the molecular basis of this variation remains incompletely understood. Here, we characterize an underexplored regulatory mechanism of the pro-inflammatory IL-18 pathway, centered on a truncated

Identifiers

PMID42244664
PMCPMC13232192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.