Evidence map›Paper›PMID 42244656›Full record

ArticlebioRxiv : the preprint server for biology2026

Vagus nerve stimulation limits colonic inflammation through distinct neuroimmune circuitry shaped by inflammatory history.

Kristina Sanchez, Jungjae Park, Emmy Tay, Gatha Pore, Abigail Wagner, Sarah Lee, Jane Li, Ayra Mirza, Melanie Gareau, Colin Reardon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristina SanchezVM: Anatomy, Physiology & Cell Biology.
Jungjae ParkVM: Anatomy, Physiology & Cell Biology.
Emmy TayVM: Anatomy, Physiology & Cell Biology.
Gatha PoreVM: Anatomy, Physiology & Cell Biology.
Abigail WagnerVM: Anatomy, Physiology & Cell Biology.
Sarah LeeVM: Anatomy, Physiology & Cell Biology.
Jane LiVM: Anatomy, Physiology & Cell Biology.
Ayra MirzaVM: Anatomy, Physiology & Cell Biology.
Melanie GareauVM: Anatomy, Physiology & Cell Biology.
Colin ReardonVM: Anatomy, Physiology & Cell Biology.ORCID 0000-0003-2204-8091

Funding

Coordination of mucosal immune response to enteric bacterial pathogens by nociceptive innervationR01AI150647 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI REARDON, COLIN · 2020 to 2024
$2.4M
Neuroimmune control of lung inflammationR56AI179656 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI REARDON, COLIN · 2024 to 2024
$350k
NIAID NIH HHS R01 AI150647NIAID NIH HHS R56 AI179656
6 · The paper itself

Abstract

Bidirectional communication between the nervous and immune systems has been demonstrated to limit or enhance immune cell function across organ systems and conditions. Although these neuroimmune circuits can become activated as an anti-inflammatory reflex, vagus nerve stimulation

Indexed as

endotoxemiainflammationintestinal inflammationneuroimmuneneuroimmunology

Identifiers

PMID42244656
PMCPMC13232180

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.