Evidence map›Paper›PMID 42244654›Full record

ArticlebioRxiv : the preprint server for biology2026

Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion.

Matthew B Pomrenze, Jason M Tucciarone, Gavin C Touponse, Nicholas Denomme, BaDoi N Phan, Robyn St Laurent, Julia A Galiza Soares, Daniel F Cardozo Pinto, Michaela Y Guo, Jinhee Baek and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Matthew B PomrenzeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-9032-5911
Jason M TucciaroneNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-6053-2952
Gavin C TouponseNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-8087-3351
Nicholas DenommeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-7631-0385
BaDoi N PhanComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0001-6331-5980
Robyn St LaurentNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-3557-6056
Julia A Galiza SoaresNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0009-0002-8865-9346
Daniel F Cardozo PintoNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-6104-4643
Michaela Y GuoNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0009-0008-2835-3242
Jinhee BaekNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-0998-0047
Allen P F ChenNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Zihui ZhangNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Amei ShankNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.
Zachary FreybergDepartments of Psychiatry and Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213.ORCID 0000-0001-6460-0118
Andreas R PfenningComputational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0002-3447-9801
Neir EshelNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-5976-2013
Robert C MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-5428-5211

Funding

Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1M
Cell type specific AAVs to study reward and cognitionUF1MH130881 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BYRNE, LEAH, PFENNING, ANDREAS ROBERT · 2022 to 2022
$6.9M
Interpreting the regulatory mechanisms underlying the predisposition to substance use disordersDP1DA046585 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PFENNING, ANDREAS ROBERT · 2018 to 2022
$2.4M
Novel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegenerationR01ES034037 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZACHARY FREYBERG · 2023 to 2026
$2.3M
Novel roles for the circadian transcription factor NPAS2 and striatal dopamine D3 receptor signaling in diurnal fentanyl craving and relapseR01DA061243 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ZACHARY FREYBERG, Ryan W Logan · 2024 to 2026
$1.4M
Novel dopaminergic mechanisms of islet hormone secretion and antipsychotic drug-induced metabolic disturbancesR01DK124219 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY · 2021 to 2023
$1.2M
Neural circuits of frustrationK08MH123791 · NIMH · STANFORD UNIVERSITY · PI ESHEL, NEIR · 2020 to 2024
$1.2M
A patch circuit dissection of opioid addictionK08DA055157 · NIDA · STANFORD UNIVERSITY · PI Jason M Tucciarone · 2023 to 2026
$761k
Ultra-fast high-resolution imaging of whole mouse brain for the study of drug addictionR21DA052419 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$448k
Modulation of protracted opioid withdrawal by dorsal raphe dynorphin neuronsK99DA056573 · NIDA · STANFORD UNIVERSITY · PI POMRENZE, MATTHEW B · 2022 to 2023
$317k
Integrating primate-rodent cell types and epigenomics to identify conservation in substance addictionF30DA053020 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHAN, BADOI NGUYEN · 2021 to 2024
$204k
NIDA NIH HHS DP1 DA046585NIDA NIH HHS F30 DA053020NIDA NIH HHS K08 DA055157NIDA NIH HHS K99 DA056573NIDA NIH HHS P50 DA042012NIDA NIH HHS R01 DA061243NIDA NIH HHS R21 DA052419NIDDK NIH HHS R01 DK124219NIEHS NIH HHS R01 ES034037NIMH NIH HHS K08 MH123791NIMH NIH HHS UF1 MH130881
6 · The paper itself

Abstract

The opioid crisis has emphasized the need for more effective treatments for opioid use disorder (OUD)

Identifiers

PMID42244654
PMCPMC13232341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.