Evidence map›Paper›PMID 42244621›Full record

ArticlebioRxiv : the preprint server for biology2026

Naturalistic behavior and self-generated neural activity predictive of self-correction.

Shijie Gu, Chenyan Liu, Anna K Gillespie, Rhino Nevers, Eric L Denovellis, Michael E Coulter, Kenneth Kay, Loren M Frank

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shijie GuUC Berkeley - UCSF Joint Graduate Program in Bioengineering, University of California, San Francisco, 94143, USA.ORCID 0000-0001-6257-5756
Chenyan LiuDepartment of Physiology, University of California, San Francisco, 94143, USA.ORCID 0009-0001-5065-6396
Anna K GillespieDepartment of Physiology, University of California, San Francisco, 94143, USA.ORCID 0000-0003-0980-2408
Rhino NeversNeuroscience Graduate Program, University of California San Francisco, San Francisco, 94143, USA.ORCID 0000-0003-2144-6952
Eric L DenovellisDepartment of Physiology, University of California, San Francisco, 94143, USA.ORCID 0000-0003-4606-087X
Michael E CoulterDepartment of Physiology, University of California, San Francisco, 94143, USA.ORCID 0000-0003-0357-351X
Kenneth KayDepartment of Physiology, University of California, San Francisco, 94143, USA.ORCID 0000-0003-3161-7217
Loren M FrankDepartment of Physiology, University of California, San Francisco, 94143, USA.ORCID 0000-0002-1752-5677

Funding

Real-time manipulations to understand and improve memory processesK99AG068425 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GILLESPIE, ANNA KATHLEEN · 2020 to 2022
$323k
NIA NIH HHS K99 AG068425
6 · The paper itself

Abstract

Changing one's mind - revising a past decision independently of external cues - can lead to better outcomes, but its neural basis remains poorly understood. We therefore developed a challenging spatial task for rats where a conflict between innate foraging biases and task rules leads to abundant, spontaneous, and characteristically corrective changes-of-mind (COMs). Neural recordings in the hippocampus, a brain region implicated in counterfactual thinking, revealed two distinct stages wherein more local representations gave way to representations of distant alternatives after animals had begun to reverse course. These representations predicted their eventual choice, and often serially encoded trial start and end locations. Our novel task paradigm reveals distinct representational phases engaged during self-correction and uncovers a rich repertoire of hippocampal spatial representations tied to behavior.

Identifiers

PMID42244621
PMCPMC13232212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.