Evidence map›Paper›PMID 42244614›Full record

ArticlebioRxiv : the preprint server for biology2026

Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD

Miguel López Rivera, Renee B Chang, Colin M Lewis, Romi Hadary, Julia M Kovalski, Krista G Freeman, Zhen-Yu J Sun, Rotem Sorek, Graham F Hatfull, Philip J Kranzusch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miguel López RiveraDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0008-0939-695X
Renee B ChangDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6298-7005
Colin M LewisDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Romi HadaryDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Julia M KovalskiDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Krista G FreemanDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Zhen-Yu J SunDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Rotem SorekDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Graham F HatfullDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-6705-6821
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4943-733X

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Bacteriophage diversity, dynamics, function, and exploitationR35GM131729 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Graham F. Hatfull · 2019 to 2026
$3.6M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R35 GM131729NIH HHS S10 OD021527
6 · The paper itself

Abstract

Bacterial, plant, and animal cells synthesize nucleotide immune signals as a conserved strategy to defend against viral infection

Identifiers

PMID42244614
PMCPMC13232231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.