Evidence map›Paper›PMID 42244605›Full record

ArticlebioRxiv : the preprint server for biology2026

PIEZO1-mediated mechanosensation links aging to bladder dysfunction.

Yasmeen M F Hamed, Vikram Joshi, Kevin Wilhelm, Luis O Romero, Olivia D Solomon, Tammy B Kwok, Eskarleth D Lopez Gonzalez, Monica M Ridlon, Shriya Pendyala, Catherine M Calhoun and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yasmeen M F HamedGraduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-6071-2024
Vikram JoshiEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4625-9427
Kevin WilhelmGraduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-2686-0976
Luis O RomeroDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-9855-7592
Olivia D SolomonDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0008-5929-9103
Tammy B KwokDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1807-1822
Eskarleth D Lopez GonzalezDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5874-7199
Monica M RidlonDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-8605-4453
Shriya PendyalaDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-6977-0095
Catherine M CalhounDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0009-6396-6017
Alexa E MartinezDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9376-5368
Jennifer K AsmussenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-9280-0333
Kimberly Keil StietzDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-7006-9420
Chad M VezinaDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-7058-5399
Valeria VásquezDepartment of Biochemistry and Molecular Biology, Center for Membrane Biology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-8494-1534
Olivier LichtargeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-4057-7122
Arthur BeyderEnteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9225-4854
Kara L MarshallDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-1722-7941

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2014 to 2023
$12.8M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
MECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLSR01DK052766 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR, FARRUGIA, GIANRICO · 1997 to 2025
$8.3M
YEARS 19 - 23: BCM POST-BACCALAUREATE RESEARCH EDUCATION PROGRAMR25GM069234 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 2003 to 2024
$7.5M
Mechanotransduction in gastrointestinal physiologyR01DK123549 · NIDDK · MAYO CLINIC ROCHESTER · PI Arthur Beyder · 2019 to 2026
$3.7M
Molecular mechanisms of mechanosensing in the urinary tractR00DK128621 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI MARSHALL, KARA L · 2022 to 2024
$737k
Linear Ion Trap - Quadrupole LC-MS SystemS10OD032292 · OD · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2022 to 2022
$592k
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
NCRR NIH HHS S10 RR027926NIDDK NIH HHS R00 DK128621NIDDK NIH HHS R01 DK052766NIDDK NIH HHS R01 DK123549NIDDK NIH HHS U54 DK104310NIEHS NIH HHS T32 ES007015NIGMS NIH HHS R25 GM069234NIH HHS S10 OD032292
6 · The paper itself

Abstract

Aging is accompanied by profound changes in bladder function, leading to increased urinary frequency and incontinence that impair quality of life in humans and are recapitulated in mouse models. Bladder filling and emptying rely on precise mechanosensory feedback, yet how aging alters this sensory control remains unclear. PIEZO ion channels convert mechanical forces into cellular signals essential for bladder fullness sensation. Using inducible smooth-muscle specific

Identifiers

PMID42244605
PMCPMC13232120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.