Evidence map›Paper›PMID 42244586›Full record

ArticlebioRxiv : the preprint server for biology2026

SHIP1 partitions between cortical oscillations and membrane puncta to regulate neutrophil chemotaxis.

Althea Amaris, Grace L Waddell, Asa J Noteboom, Sophia Doerr, Emma E Drew, Sean R Collins, Scott D Hansen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Althea AmarisInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Grace L WaddellInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Asa J NoteboomInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Sophia DoerrInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Emma E DrewInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.
Sean R CollinsDepartment of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616.ORCID 0000-0002-4276-5840
Scott D HansenInstitute of Molecular Biology, University of Oregon, Eugene, OR 97403.ORCID 0000-0001-7005-6200

Funding

MOLECULAR BIOLOGY AND BIOPHYSICST32GM007759 · NIGMS · UNIVERSITY OF OREGON · PI NOLEN, BRADLEY J · 1985 to 2021
$8.5M
Deciphering the mechanism of SHIP1 regulation in human neutrophilsR01GM143406 · NIGMS · UNIVERSITY OF OREGON · PI HANSEN, SCOTT DAVID · 2021 to 2025
$1.7M
Actin gating of crosstalk between Rho GTPases in cell migrationR01GM148769 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Sean Ryan Collins · 2023 to 2026
$1.7M
NIGMS NIH HHS R01 GM143406NIGMS NIH HHS R01 GM148769NIGMS NIH HHS T32 GM007759
6 · The paper itself

Abstract

As frontline defenders in the innate immune system, neutrophils traffic to sites of infection by detecting chemical gradients, polarizing, and migrating towards foreign pathogens. This requires communication between small GTPases, phosphatidylinositol phosphate (PIP) lipids, and the actin cytoskeleton to generate forces that drive leading-edge membrane protrusions. Central to the coordination of these signaling events is the hematopoietic-cell-specific 5-inositol lipid phosphatase SHIP1 (or INPP5D), which shapes PIP lipid domains by dephosphorylating phosphatidylinositol-(3,4,5)-trisphosphate (PIP

Identifiers

PMID42244586
PMCPMC13232248

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.