Evidence map›Paper›PMID 42244584›Full record

ArticlebioRxiv : the preprint server for biology2026

FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia.

Phoebe Loo, Margaret Pan, Man Zhao, Stavros Melemenidis, Dixin Chen, Lucy Whitmore, Sara Richter, Frederick M Dirbas, Kerriann M Casey, Edward E Graves and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Phoebe LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Margaret PanDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Man ZhaoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Dixin ChenDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Lucy WhitmoreDepartment of Surgery, Stanford University School of Medicine, Stanford CA 94305.
Sara RichterDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Frederick M DirbasDepartment of Surgery, Stanford University School of Medicine, Stanford CA 94305.
Kerriann M CaseyDepartment of Comparative Medicine, Stanford University School of Medicine, Stanford CA 94305.
Edward E GravesDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Michael W EpperlyDepartment of Radiation Oncology, University of Pittsburgh, Pittsburgh PA 15260.
Joel GreenbergerDepartment of Radiation Oncology, University of Pittsburgh, Pittsburgh PA 15260.
Billy W LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.
Erinn B RankinDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305.ORCID 0000-0002-2521-0544

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
NCI NIH HHS P01 CA244091
6 · The paper itself

Abstract

Patients with Fanconi anemia (FA) are particularly susceptible to developing squamous cell carcinoma of the head and neck due to impaired DNA repair pathways. However, their hypersensitivity to DNA damaging agents can limit effective treatment with standard radiotherapy due to severe side effects and complications. In pre-clinical models, ultra-rapid FLASH radiotherapy (FLASH) reduces radiation-induced toxicity in normal tissues while maintaining similar tumor control compared to conventional dose rate radiotherapy (CONV). Here, we investigated the safety of FLASH for treatment of the head and neck in a mouse model of FA. 129/Sv wild-type (WT) and

Indexed as

DNA damageFLASHoral mucositisradiation therapy

Identifiers

PMID42244584
PMCPMC13232302

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.