Evidence map›Paper›PMID 42244539›Full record

ArticlebioRxiv : the preprint server for biology2026

Improved short nascent strand sequencing (iSNS-seq) enhances DNA replication origin detection and reduces non-origin biases.

Miiko Sokka, John M Urban, Nicola Neretti, Susan A Gerbi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Miiko SokkaDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 185 Meeting Street, Providence, Rhode Island, 02912, USA.ORCID 0000-0002-3091-3754
John M UrbanDepartment of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, Maryland, 21218, USA.ORCID 0000-0001-9270-6569
Nicola NerettiDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 185 Meeting Street, Providence, Rhode Island, 02912, USA.ORCID 0000-0002-9552-1663
Susan A GerbiDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 185 Meeting Street, Providence, Rhode Island, 02912, USA.ORCID 0000-0003-2148-7180

Funding

DNA Amplification in the Sciara GenomeR01GM121455 · NIGMS · BROWN UNIVERSITY · PI GERBI, SUSAN A · 2017 to 2021
$1.4M
NIGMS NIH HHS R01 GM121455
6 · The paper itself

Abstract

Identifying DNA replication origins in human and other metazoan genomes has been challenging, as highlighted by the fact that various methods for mapping them have produced conflicting results. A popular method, short nascent strand sequencing (SNS-seq), enriches newly replicated short single-stranded DNA by size selection and

Indexed as

DNA replication origin mappingDNA replication originsNS-seqSaccharomyces cerevisiaeshort nascent strand sequencingSNS-seqλ-exonuclease

Identifiers

PMID42244539
PMCPMC13232316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.