Evidence map›Paper›PMID 42244533›Full record

ArticlebioRxiv : the preprint server for biology2026

Lipogenesis-driven EGFR palmitoylation enables metastatic immune evasion in triple-negative breast cancer.

Myung Soo Ko, Divya Ramchandani, Glenn Simmons, Jason McCormick, Sebastian Carrasco, Arshdeep Singh, Liron Yoffe, Guoan Zhang, Vivek Mittal

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Myung Soo KoDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-0053-3697
Divya RamchandaniDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Glenn SimmonsDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, USA.
Jason McCormickFlow Cytometry Core Facility, Weill Cornell Medicine, New York, NY, USA.
Sebastian CarrascoLaboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, Rockefeller University, New York, NY, USA.
Arshdeep SinghDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Liron YoffeDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-3040-8205
Guoan ZhangProteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY, USA.
Vivek MittalDepartment of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.

Funding

Copper-mediated metabolic reprogramming and ECM alterations in TNBC metastasisR01CA257254 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MITTAL, VIVEK, VAHDAT, LINDA THERESA · 2021 to 2025
$2.7M
High-parametric flow cytometry cell sorter for human immunology studies.S10OD032397 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANANDASABAPATHY, NIROSHANA · 2023 to 2023
$817k
NCI NIH HHS R01 CA257254NIH HHS S10 OD032397
6 · The paper itself

Abstract

Metastasis is the leading cause of death in triple-negative breast cancer (TNBC), yet how tumor cells evade immune recognition during dissemination remain unclear. Here, we show that de novo lipogenesis drives metastatic immune evasion through FASN-mediated palmitoylation of EGFR. This modification establishes a lipid-dependent membrane signaling scaffold that sustains PI3K-AKT-mTOR signaling independently of MAPK compensation, thereby suppressing MHC-I antigen presentation through post-translational regulation. As a result, metastatic-competent cells escape CD8+ T cell surveillance and colonize distant organs. Genetic or pharmacologic inhibition of fatty acid synthase (FASN), or expression of palmitoylation-deficient EGFR mutants restores MHC-I surface expression, unleashes robust CD8

Indexed as

antigen presentationCD8+ T cellsEGFR palmitoylationFatty acid metabolismFatty acid synthase (FASN)ImmunometabolismimmunosuppressionKRAS-mutant epithelial tumorslung metastasismetastatic immune escapePI3K-mTOR signalingTriple-negative breast cancer

Identifiers

PMID42244533
PMCPMC13232100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.