Evidence map›Paper›PMID 42244524›Full record

ArticlebioRxiv : the preprint server for biology2026

MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion.

Xuebing Leng, Lance A Buchness, Christine I Rafie, Panagiotis I Vlantis, Svetlana Ristin, Miguel A Gallardo, Supipi L Auwardt, Natasha K Khatwani, Yuan-De Tan, Yuguang Ban and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xuebing LengDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Lance A BuchnessDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Christine I RafieSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Panagiotis I VlantisDepartment of Biochemistry and Molecular Biology, University of Miami, Miami, Florida.
Svetlana RistinDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Miguel A GallardoDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Supipi L AuwardtDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Natasha K KhatwaniSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Yuan-De TanSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Yuguang BanSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Corneliu M SologonSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Benjamin B CurrallSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Sion L WilliamsSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Kevin Van der JeughtDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Jashodeep DattaSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Alejandro VillarinoDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.
Aristeidis G TelonisSylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
Erietta StelekatiDepartment of Microbiology and Immunology, University of Miami, Miami, Florida.ORCID 0000-0002-1987-0124

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kerry L Burnstein · 2019 to 2026
$24.1M
Epigenetic regulation of exhausted CD8 T cells via the miR-29a-TET2 axisR01AI183292 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ERIETTA STELEKATI · 2024 to 2026
$1.5M
Disrupting MDSC-fibroblast interactions to overcome chemoimmunotherapy resistance in pancreatic cancerR37CA292843 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Jashodeep Datta · 2024 to 2026
$1.1M
Delivering miR-29a to enhance anti-viral and anti-tumor responses in vivoR21AI178184 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STELEKATI, ERIETTA · 2024 to 2025
$415k
A novel immunotherapy for pancreatic cancer using micro-RNA-29aF31CA294908 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Christine Isabelle Rafie · 2024 to 2026
$164k
NCI NIH HHS F31 CA294908NCI NIH HHS P30 CA240139NCI NIH HHS R37 CA292843NIAID NIH HHS R01 AI183292NIAID NIH HHS R21 AI178184
6 · The paper itself

Abstract

CD8 T cells mediate protective immune responses. However, persisting antigens such as chronic viruses or tumors redirect CD8 T cell differentiation to a sub-optimal, epigenetically defined state called exhaustion. Exhausted T cells (T

Indexed as

CD8 T cellsimmunotherapymicroRNA-29aPD-1reinvigorationT cell exhaustion

Identifiers

PMID42244524
PMCPMC13232195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.