Evidence map›Paper›PMID 42244445›Full record

ArticleObesity (Silver Spring, Md.)2026

Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome.

Victoria L Fleming-Batayneh, Brian C Helsel, Lauren T Ptomey, Benjamin L Handen, Mark Mapstone, Melissa Petersen, Sharon J Krinsky-McHale, Christy L Hom, Davneet Minhas, Weiquan Luo and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Victoria L Fleming-BataynehWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-6788-294X
Brian C HelselDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID https://orcid.org/0000-0003-3362-3581
Lauren T PtomeyDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID https://orcid.org/0000-0002-1705-1643
Benjamin L HandenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mark MapstoneDepartment of Neurology, University of California Irvine School of Medicine, Irvine, California, USA.
Melissa PetersenDepartment of Family Medicine Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Sharon J Krinsky-McHaleDepartment of Psychology, New York Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA.ORCID https://orcid.org/0000-0002-7205-7319
Christy L HomDepartment of Psychiatry and Human Behavior, University of California, Irvine, California, USA.ORCID https://orcid.org/0000-0003-0266-0961
Davneet MinhasDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Weiquan LuoDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Charles LaymonDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joseph H LeeTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Annie CohenBehavioral Health Service Line, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Beau M AncesDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Margaret PulsiferDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
H Diana RosasDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9360-7511
Florencia LaiDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Shahid H ZamanDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-1639-6014
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0000-0003-1115-6396
Dana TudorascuDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Julie PriceDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Fredrick SchmittDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
Bradley T ChristianWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-9653-559X
Ozioma OkonkwoDepartment of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sigan L HartleyWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alzheimer Biomarkers Consortium‐Down Syndrome (ABC‐DS) Investigators

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, JOSEPH HYUNGWOO · 2020 to 2025
$103.7M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0M
UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI YASSA, MICHAEL A · 2000 to 2019
$37.0M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Teresa Gomez-Isla · 2019 to 2026
$36.5M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
National Centralized Repository for Alzheimer Disease and Related Dementias U24 AG21886NCATS NIH HHS UL1 TR001414NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002366NCATS NIH HHS UL1 TR002373NIA NIH HHS F31 AG085730NIA NIH HHS K01 AG083130NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG072973NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG070028NIA NIH HHS U01 AG051406NIA NIH HHS U01 AG051412NIA NIH HHS U19 AG068054NICHD NIH HHS P50 HD105353NIHR Cambridge Biomedical Research CentreWindsor Research Unit
6 · The paper itself

Abstract

objectiveAdults with Down syndrome (DS) often show elevated systemic inflammation, but the association with obesity, aging, and Alzheimer's disease (AD) pathology is not well understood.

methodsData were drawn from 188 nondemented adults with DS participating in the Alzheimer Biomarkers Consortium-DS (ABC-DS). Participants completed clinical assessments, blood draws, and neuroimaging. Plasma biomarkers included indicators of general, pro-, and anti-inflammation. Mixed linear models tested associations between BMI, age, PET-measured amyloid burden, and inflammatory biomarkers, adjusting for sex, trisomy type, and collection site. False discovery rate correction was applied.

resultsThe majority of the participants met criteria for obesity. Higher BMI was significantly associated with elevated levels of CRP, IL-6, TNF-α, B2M, IL-18, and slCAM-1 (p < 0.05). Older age was significantly associated with higher B2M (β = 1.22e + 05, p < 0.001). Amyloid burden was positively associated with IL-6 (β = 0.005, p = 0.037).

conclusionsObesity, aging, and amyloid burden relate to systemic inflammation in adults with DS. Obesity showed the strongest and most consistent associations, emphasizing the value of regular monitoring and weight management strategies to help reduce inflammation. Aging and early amyloid accumulation showed more limited links with systemic inflammation; future work should examine whether these processes are more closely related to biomarkers of neuroinflammation as AD progresses.

Indexed as

AgingAmyloidDown SyndromeInflammationObesityAdultAgedAlzheimer DiseaseBiomarkersBody Mass IndexC-Reactive ProteinFemaleHumansInterleukin-18Interleukin-6MaleAmyloidBiomarkersC-Reactive ProteinInterleukin-18Interleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID42244445
PMCPMC13306135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.