ArticleESC heart failure2026
Oxygen utilization during moderate-intensity resistance and aerobic exercise in arrhythmogenic cardiomyopathy: the central role of the periphery.
Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsTo quantify central oxygen delivery (O2D), peripheral oxygen extraction, and muscle diffusive oxygen conductance (DmO2) during upper-extremity resistance and lower-extremity aerobic exercise in patients with arrhythmogenic cardiomyopathy (ACM). METHODS AND
resultsNineteen patients with ACM underwent invasive cardiopulmonary exercise testing with right heart and radial artery catheterization. Participants performed 1-min isometric handgrip (IM-HG) and bicep curl (BC) exercise at 70% maximal voluntary contraction, and 20- and 40-min supine cycling (CYC-20, CYC-40) at the first ventilatory threshold. Exercise pulmonary hypertension, defined by a cardiac output to mean pulmonary artery slope >3 mmHg/L/min, did not occur (mean 0.67 mmHg/L/min). Whole-body oxygen uptake (V̇O2) increased significantly across all modes (P < .001); however, central O2D did not increase significantly during IM-HG or BC and rose only modestly during cycling. In contrast, peripheral O2 extraction and DmO2 increased significantly across all modalities (P < .001). Dominance analysis revealed that DmO2 accounted for 77% of the variance in V̇O2 pooled across all conditions, whereas O2D accounted for only 23%.
conclusionsModerate-intensity isometric and dynamic resistance and aerobic exercise in ACM is mediated by a predominantly peripheral, rather than central, physiological stress in our small ACM sample. This may provide preliminary results for a physiological rationale for safe exercise in this population.
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