Evidence map›Paper›PMID 42244394›Full record

ArticleAutism research : official journal of the International Society for Autism Research2026

Linking Brain Morphometry to Psychometric Measures and Energy-Metabolic Biomarkers in Adults With Autism Spectrum Disorder.

Eleonora Esposto, Kathrin Nickel, Dominique Endres, Kimon Runge, Katharina Domschke, Thomas Lange, Marco Reisert, Anke Schumann, Cinzia Niolu, Ludger Tebartz van Elst and 1 more

Abstract read
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In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eleonora EspostoDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0009-0003-8571-9515
Kathrin NickelDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Dominique EndresDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Kimon RungeDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Thomas LangeDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-7467-8143
Marco ReisertDivision of Medical Physics, Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Anke SchumannCenter for Children's and Women's Medicine, Center for Pediatrics, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center-University of Freiburg/Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Cinzia NioluDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Ludger Tebartz van ElstDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Simon MaierDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Funding

Deutsche Forschungsgemeinschaft MA 7813/1-1Deutsche Forschungsgemeinschaft TE 280/15-1
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is associated with differences in neurodevelopment and altered metabolism, yet the interplay between brain morphometry, mitochondrial and energy metabolism biomarkers, and autistic traits in adults remains poorly understood. This study investigates the link between brain structure, psychometric measures, and both central and peripheral metabolic biomarkers in adults with ASD. We studied 145 adults, including 74 with ASD and 71 control participants (CON) using high-resolution 3-Tesla MRI to assess cortical thickness, subcortical and global brain volumes. Central energy metabolism was indexed by the posterior-cingulate lactate + threonine (Lac

Indexed as

Autism Spectrum DisorderBrainEnergy MetabolismAdolescentAdultAttention Deficit Disorder with HyperactivityBiomarkersFemaleHumansMagnetic Resonance ImagingMalePsychometricsYoung AdultBiomarkersacylcarnitinesautism spectrum disorderbrain morphometrycortical thicknessmagnetic resonance spectroscopymitochondrial energy biomarkers

Identifiers

PMID42244394
PMCPMC13377343

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.