Evidence map›Paper›PMID 42244361›Full record

ArticleJournal of the science of food and agriculture2026

Probiotic supplementation promotes bone development, immune maturation, and cognitive function in growing mice.

Mingjie Li, Haiqin Chen, Qing Zhang, Xing Zhao, Xinkai Sun, Shumao Cui, Qixiao Zhai, Linsen Zhao, Jianxin Zhao, Bo Yang and 1 more

Abstract read
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In one paragraph

Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingjie LiState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
Haiqin ChenState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.ORCID https://orcid.org/0000-0002-2359-2622
Qing ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.
Xing ZhaoHebei Inatural Bio-Tech Co. Ltd, Shijiazhuang, China.
Xinkai SunHebei Inatural Bio-Tech Co. Ltd, Shijiazhuang, China.
Shumao CuiState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.ORCID https://orcid.org/0000-0002-7055-0484
Qixiao ZhaiState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.ORCID https://orcid.org/0000-0002-0605-2675
Linsen ZhaoHebei Inatural Bio-Tech Co. Ltd, Shijiazhuang, China.
Jianxin ZhaoState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.ORCID https://orcid.org/0000-0003-4516-0799
Bo YangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.ORCID https://orcid.org/0000-0002-1347-3718
Wei ChenState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China.

Funding

Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu ProvinceFundamental Research Funds for the Central UniversitiesResearch Program of State Key Laboratory of Food Science and Resources, Jiangnan University
6 · The paper itself

Abstract

backgroundEarly life is a critical window for bone mineral deposition, immune system development, and neurodevelopment. This study evaluated the effects of four probiotic strains on bone growth and regulation of immune function and cognitive function using a growing mouse model, thereby providing preclinical evidence for potential applications in supporting infant and child health.

resultsFemale BALB/c mouse pups received a daily oral gavage of 1 × 10

conclusionCollectively, these findings suggest that L. paracasei L578 enhances bone formation metabolism, stimulates longitudinal bone growth, increases bone mass, regulates mucosal humoral immunity, and improves cognitive function, positioning it as a promising probiotic for supporting development. © 2026 Society of Chemical Industry.

Indexed as

Bone DevelopmentCognitionProbioticsAnimalsBifidobacterium bifidumBone Morphogenetic Protein 2Dietary SupplementsFemaleHumansImmunoglobulin AImmunoglobulin GInterferon-gammaMiceMice, Inbred BALB COsteocalcinBone Morphogenetic Protein 2Immunoglobulin AImmunoglobulin GInterferon-gammaOsteocalcinbone formationcognitive functionimmune functionsjuvenile miceprobiotics

Identifiers

PMID42244361
PMCPMC13442953

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.