ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Effects of bariatric surgery on glucose and lipid metabolism in obese mice: An integrated transcriptomic and LC
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesObesity and its associated disorders of glucose and lipid metabolism have become increasingly significant public health concerns. Bariatric surgery is an effective intervention for severe obesity and related metabolic comorbidities. This study aims to investigate the effects of bariatric surgery on glucose and lipid metabolism in high-fat diet (HFD)-induced obese mice.
methodsAn obesity mouse model was established. Four-week-old male C57BL/6J mice (
resultsFour weeks after surgery, compared with the HFD-HFD and HFD-SHAM groups, the HFD-SG group showed significantly reduced body weight and food intake (all
conclusionsSG significantly reduced body weight and food intake, improved glucose tolerance and insulin sensitivity, and corrected lipid metabolism disorders in HFD-induced obese mice. Bariatric surgery regulates steroid biosynthesis and folate-mediated one-carbon metabolism pathways in adipose tissue, altering key gene and metabolite expression profiles. These findings suggest that bariatric surgery improves systemic glucose and lipid metabolism by remodeling metabolic pathways in adipose tissue, providing novel molecular insights for the treatment of obesity and related metabolic diseases.
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