Evidence map›Paper›PMID 42244310›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026

[Causal relationship between the triglyceride

Yina Wang, Yuanguo Chen, Yang Wang, Lu Chen, Meilong Yin, Xiao Xiao, Jing Huang, Jingjie Kuang, Yayong Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Associations of candidate gene polymorphisms, gut microbiota, and their interactions with NAFLD in obese children].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yina WangDepartment of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011. wangyina@csu.edu.cn.
Yuanguo ChenDepartment of Emergency, Third Xiangya Hospital, Central South University, Changsha 410013.
Yang WangDepartment of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011.
Lu ChenCenter of Geriatrics (Medical Care Center), Hainan General Hospital, Hainan Affiliated Hospital, Hainan Medical University, Haikou 571199.
Meilong YinDepartment of Emergency, Third Xiangya Hospital, Central South University, Changsha 410013.
Xiao XiaoDepartment of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011.
Jing HuangDepartment of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011.
Jingjie KuangCadre Ward, 921 Hospital, the People's Liberation Army Joint Logistics Support Force, Changsha 410003, China.
Yayong LiDepartment of Emergency, Third Xiangya Hospital, Central South University, Changsha 410013. liyy999@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNon-alcoholic fatty liver disease (NAFLD) has become a major public health issue that seriously affects human health. This study aims to employ a two-sample Mendelian randomization (MR) approach to investigate the causal relationship between the triglyceride-glucose (TyG) index and NAFLD, aiming to explore the potential impact of the TyG index on NAFLD.

methodsSummary-level data for the TyG index were obtained from published genome-wide association study (GWAS) based on the UK Biobank, while GWAS summary data for NAFLD were retrieved from the IEU Open GWAS database. The inverse-variance weighted (IVW) method was used as the primary analysis, complemented by the weighted median (WM) method and the MR-Egger regression to further assess the causal relationship. Cochran's

resultsThe MR-PRESSO method identified outliers (rs2081687 and rs483082), which were excluded. After removal, IVW analysis showed that the TyG index was significantly positively associated with NAFLD (

conclusionsThis MR study suggests a causal relationship between the TyG index and NAFLD. Elevated TyG index levels are associated with an increased risk of NAFLD, with no evidence supporting reverse causation. These findings provide a reference for identifying potential risk factors for NAFLD and developing effective prevention strategies.

Indexed as

Blood GlucoseMendelian Randomization AnalysisNon-alcoholic Fatty Liver DiseaseTriglyceridesGenome-Wide Association StudyHumansPolymorphism, Single NucleotideBlood GlucoseTriglyceridescausal relationshipgenome-wide association studyMendelian randomizationnon-alcoholic fatty liver diseaserisktriglyceride-glucose index

Identifiers

PMID42244310
PMCPMC13229661

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.