ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Analysis of risk factors and construction of a predictive model for perioperative urosepsis].
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesUrosepsis is a common and severe perioperative complication in patients with upper urinary tract calculi. This study aims to analyze the risk factors for perioperative urosepsis in patients with upper urinary tract calculi complicated by pyonephrosis and to construct a predictive model.
methodsClinical data of patients with upper urinary tract calculi complicated by pyonephrosis who underwent surgical treatment at Xiangya Hospital, Central South University, between January 1, 2019 and September 30, 2023 were retrospectively collected. According to whether patients developed urosepsis, they were divided into a urosepsis group and a non‑urosepsis group. Baseline characteristics, preoperative indicators, and intraoperative and postoperative monitoring parameters were compared between the 2 groups. Least absolute shrinkage and selection operator (LASSO) regression combined with multivariate logistic regression analysis was used to identify risk factors. A nomogram prediction model for perioperative progression from pyonephrosis to urosepsis was established, and its predictive performance was evaluated using receiver operating characteristic (ROC) curve analysis.
resultsA total of 221 patients with upper urinary tract calculi complicated by pyonephrosis who underwent surgery were included, among whom 45 (20.4%) patients were diagnosed with urosepsis and 176 (79.6%) patients were classified as non‑urosepsis. Significant differences were observed between the urosepsis group and the non‑urosepsis group in age, American Society of Anesthesiologists (ASA) classification, highest perioperative body temperature, preoperative laboratory indicators, comorbidities (including diabetes mellitus, cardiovascular and cerebrovascular diseases, and autoimmune diseases), staged surgery, intraoperative fluid infusion volume, operative time, stone size, and length of intensive care unit stay (all
conclusionsHigh body temperature and elevated PCT levels are independent risk factors for perioperative urosepsis in patients with upper urinary tract calculi complicated by pyonephrosis. The predictive model constructed based on these factors may provide a preliminary clinical reference for the prevention and management of perioperative urosepsis.
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