ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
Solamargine alleviates liver fibrosis by regulating YAP signaling in hepatic stellate cells.
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesSolamargine is a natural compound derived from the traditional Chinese medicinal plant
methodsLX-2 cells were treated with solamargine (1.25 and 2.50 μmol/L) for 24 h. Cell proliferation was assessed using the cell counting kit-8 (CCK-8) assay. The expression levels of fibrosis-related genes and proteins were detected by real-time quantitative PCR (RT-qPCR) and Western blotting analysis. C57BL/6J mice were randomly divided into a control group, CCl
resultsCCK-8 assays showed that treatment with 1.25 and 2.50 μmol/L solamargine for 24 and 48 h significantly reduced the proliferative activity of LX-2 cells compared with the control group (all
conclusionsSolamargine attenuated liver fibrosis by suppressing YAP signaling and downregulating downstream targets such as
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