ArticleMolecular imaging and radionuclide therapy2026
Validation of Simplified Renal Dosimetry Protocols for
Article in Molecular imaging and radionuclide therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The multi-time-point imaging method for renal dosimetry in lutetium-177 ( Methods: This retrospective study analyzed 28 kidneys obtained from 17 patients with neuroendocrine neoplasms. Renal absorbed doses from a reference four-time-point (4TP) schedule (4, 24, 72, and 120 hours) were compared with ten simplified protocols using statistical analyses of error and agreement. Results: Protocols that included the 120-hour time point demonstrated significantly higher accuracy. The 2TP (4, 24) protocol showed a profound underestimation [mean percentage error (MPE): -14.3%] and a high error. In contrast, the 2TP (24, 120) protocol showed excellent agreement [MPE: 0.57%, mean absolute percent error (MAPE): 5.5%]. Among 3TP methods, the 3TP (24, 72, 120) protocol yielded the highest accuracy (MAPE: 1.97%). Conclusion: Accurate renal dosimetry in
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