ArticleThe Journal of organic chemistry2026
Bifunctional Catalysis of a Crossed Aldol Condensation by Diamines: Impact of Tether Composition and Length.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The crossed aldol condensation between hydrocinnamaldehyde and 2,6-dimethoxybenzaldehyde was used to explore bifunctional catalysis by a set of diamines. The catalytic mechanism appears to involve nucleophilic activation of hydrocinnamaldehyde, as the enamine, and electrophilic activation of 2,6-dimethoxybenzaldehyde, as the iminium. Our goal was to learn how catalytic efficacy is influenced by variations in the molecular scaffold that displays the two primary amine groups. One set of diamines contained oligomethylene linkers of 4 to 16 carbons, and another set contained oligoether linkers (-O-CH
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