Evidence map›Paper›PMID 42244090›Full record

ReviewAdvanced healthcare materials2026

Human Organoids as a Novel Tool for Vaccine Study.

Ya Wen, Siyu Chen, Cong Xu, Yujuan Zhu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ya WenResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0009-0007-4664-9453
Siyu ChenMedical School of Nantong University, Nantong, China.
Cong XuDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Yujuan ZhuResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.ORCID https://orcid.org/0009-0000-2497-5716

Funding

Jiangsu Provincial Medical Key Discipline Cultivation Unit JSDW202205Jiangsu Provincial Research Hospital YJXYY202204Jiangsu Shuangchuang Talent Program JSSCRC2024596National Natural Science Foundation of China 82102233Science and Technology Project of Nantong City JC2023037
6 · The paper itself

Abstract

Vaccines have greatly improved public health since their proper establishment, but there are fundamental disconnects in the way that vaccines are developed, namely from cells and animals, then to humans, leading to their failure in final clinical trials. Fortunately, organoids, especially immune and tumor organoids, can replicate sophisticated insights regarding human tissue architecture and functionality in organ-like 3D structures, thereby emerging as a powerful tool to bridge the gap between animals and humans. In this review, we first highlight the mechanisms of vaccine-induced protection, then discuss the development of immune and tumor organoids as novel tools for vaccine testing, design, and reverse translation. We also indicate specific hurdles facing the application of organoids in vaccinology and offer forward-looking perspectives.

Indexed as

OrganoidsVaccinesAnimalsHumansVaccinesadaptive immune responsesin vitro immune modelorganoidsvaccine discovery

Identifiers

PMID42244090
PMCPMC13356510

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.