Evidence map›Paper›PMID 42244084›Full record

ArticleCancer medicine2026

Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single-Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA.

Shuai Tan, Fang Fang, Jing Sun, Yumeng Li, Yaochi Chen, Wanling Sun

Abstract read
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In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuai TanDepartment of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Fang FangDepartment of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jing SunDepartment of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yumeng LiDepartment of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0007-1137-2167
Yaochi ChenDepartment of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wanling SunDepartment of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

Beijing Future Talent Training Program in Medical-Engineering Field MBRC0012025063Beijing High Innovation Program Spring Bud Project 2-1-008-0262Beijing High-level Overseas Returnee Talent Funding Project 2-2-008-0243Capital Medical University Science and Innovation Elite Plan Project 2024KCJY0405National Natural Science Foundation of China (NSFC) 82300161"National Natural Science Foundation of Youth Cultivation Project" of "Xuanwu Hospital, Capital Medical University, Beijing, China" QNPY2022014Natural Science Foundation of Beijing Municipality Z200022"Person of Outstanding Ability Training Program" of "Xuanwu Hospital, Capital Medical University, Beijing, China" YC20220127Xuanwu Hospital Talent Convergence Program HZ2025ZCYX003
6 · The paper itself

Abstract

backgroundThe pathogenesis of HSPCs impairment in aplastic anemia (AA) remains unclear. We focused on CD8

methodsWe have successfully established a mouse model of bone marrow failure and analyzed the immune response at the single-cell level.

resultsPlatelets regulate CD4

conclusionThe possible mechanisms of BMF in AA: based on PF4, platelet-T cell/macrophage crosstalk leads to immune overactivation and the release of cytokines such as IFN-γ and TNF-α, which attack the marrow. Therefore, transforming imbalanced CD8

Indexed as

Anemia, AplasticBone Marrow Failure DisordersAnimalsBlood PlateletsBone MarrowCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalHumansMacrophagesMiceSingle-Cell Analysisaplastic anemiabone marrow failureimmune cellsplateletsingle‐cell sequencing

Identifiers

PMID42244084
PMCPMC13238611

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.