Evidence map›Paper›PMID 42243965›Full record

ArticleEnvironmental health : a global access science source2026

Air pollution and disease progression among patients with primary glomerular disease: an expanded study with extended follow-up.

Jonathan P Troost, Abhijit V Kshirsagar, William E Smoyer, Jon Klein, Michael L Merchant, Margaret Helmuth, Laura H Mariani, Matthias Kretzler, Abigail R Smith, Forrest Lacey and 3 more

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In one paragraph

Article in Environmental health : a global access science source, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonathan P TroostMichigan Institute for Clinical & Health Research (MICHR), University of Michigan, Ann Arbor, MI, USA.
Abhijit V KshirsagarDepartments of Medicine, Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC, USA.
William E SmoyerThe Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Jon KleinDepartment of Medicine, Division of Nephrology and Hypertension, School of Medicine, Christina Lee Brown Environment Institute, University of Louisville, University of Louisville, Louisville, KY, USA.
Michael L MerchantDepartment of Medicine, Division of Nephrology and Hypertension, School of Medicine, Christina Lee Brown Environment Institute, University of Louisville, University of Louisville, Louisville, KY, USA.
Margaret HelmuthDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Laura H MarianiDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Matthias KretzlerDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Abigail R SmithDepartment of Preventive Medicine, Division of Biostatistics and Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Forrest LaceyNational Science Foundation National Center for Atmospheric Research, Boulder, CO, USA.
Lawrence S EngelDepartments of Epidemiology and Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA.
Howard TrachtmanDepartment of Pediatrics, Division of Nephrology, University of Michigan, 1150 W. Medical Center Dr, Med Sci 1/ARF 251, Ann Arbor, MI, 48109-0168, USA. howardtrachtman21@gmail.com.
Cassandra R O'LenickDepartments of Epidemiology and Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA.

Funding

NIH HHS U24DK100845 (formerly UM1DK100845), U01DK100846 (formerly UM1DK100846), U01DK100876 (formerly UM1DK100876), U01DK100866 (formerly UM1DK100866), and U01DK100867 (formerly UM1DK100867) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
6 · The paper itself

Abstract

backgroundAir pollution is increasingly recognized as a risk factor for progression of kidney disease; however, few studies have examined its impact among patients with primary glomerular disorders. To address this knowledge gap, we previously reported positive associations between fine particulate matter ≤ 2.5μm in aerodynamic diameter (PM

methodsIn this retrospective cohort study, we obtained air pollutant concentration data from NCAR based on participant residential census tract at enrollment. For each census tract and pollutant, we aggregated daily pollutant concentrations to annual averages. We used Cox proportional hazards models to estimate associations between average baseline pollutant exposure and time to kidney disease progression, defined as a 40% decline in estimated glomerular filtration rate (eGFR) or occurrence of kidney failure (eGFR) < 15 ml/min/1.73 m

resultsUse of NCAR data supported our previous findings of adverse effects of PM

conclusionOur findings highlight the importance of the systematic assessment including spatial and temporal variation of a broad range of air pollution components to determine the impact of exposure on short- and long-term outcomes in patients with primary glomerular disease (word count: 368).

Indexed as

Air PollutantsAir PollutionEnvironmental ExposureAdolescentAdultChildDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedParticulate MatterRetrospective StudiesYoung AdultAir PollutantsParticulate MatterAir pollutionBlack carbonPM2.5Primary glomerular disease

Identifiers

PMID42243965
PMCPMC13455273

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