Evidence map›Paper›PMID 42243957›Full record

ArticleJournal of nanobiotechnology2026

Bacterial outer membrane vesicle-based biomimetic nitric oxide-releasing nanogenerator for boosting antitumor efficiency of enzyme dynamic therapy via augmented autophagy and immunoactivation.

Xiling Song, Keyan Luo, Yangfeng Du, Linhao Xie, Yinming Chen, Yu Zhang, Tao Wu, Zhigang Zhou, Saiqi Wang, Xiaobing Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiling SongKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Keyan LuoKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Yangfeng DuDepartment of Oncology, Research Center of Cancer Diagnosis and Therapy, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Linhao XieDepartment of Oncology, Research Center of Cancer Diagnosis and Therapy, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Yinming ChenKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Yu ZhangKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Tao WuDepartment of Oncology, Research Center of Cancer Diagnosis and Therapy, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Zhigang ZhouDepartment of Oncology, Xiangya School of Medicine, Changde Hospital, Central South University (Changde First People's Hospital), Changde, 415000, China.
Saiqi WangDepartment of Oncology, Henan Province Engineering Research Center for of Intractable Digestive Tract Tumor Precision Therapy, Henan Province Engineering Technology Research Center for Digestive Tract Tumor Precision Therapy, Zhengzhou Key Laboratory of Precision Therapy of Gastrointestinal Cancer, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China.
Xiaobing ChenDepartment of Oncology, Henan Province Engineering Research Center for of Intractable Digestive Tract Tumor Precision Therapy, Henan Province Engineering Technology Research Center for Digestive Tract Tumor Precision Therapy, Zhengzhou Key Laboratory of Precision Therapy of Gastrointestinal Cancer, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China. zlyychenxb0807@zzu.edu.cn.
Jianfu ZhaoDepartment of Oncology, Research Center of Cancer Diagnosis and Therapy, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. zhaojianfu@jnu.edu.cn.
Siming YuKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China. siming_yu@hotmail.com.

Funding

Guangzhou Municipal Science and Technology Project 2025A03J4253Henan Province Triple-100 Program: Overseas Fellowship for Medical Science and Technology Talents HNMOT2024015Key-Area Special Project of Department of Education of Guangdong Province 2023ZDZX2001/2024ZDZX2003Medical Science and Technique Foundation of Henan Province SBGJ202301004National Natural Science Foundation of China 22475085National Natural Science Foundation of China 82372099National Natural Science Foundation of China 82573686Science and Technology Research and Development Program Joint Fund of Henan Province 235200810034
6 · The paper itself

Abstract

Recently, enzyme dynamic therapy (EDT) has attracted great attention in cancer therapy. Nevertheless, the limited H

Indexed as

Antineoplastic AgentsAutophagyBacterial Outer MembraneBiomimetic MaterialsNitric OxideAnimalsCell Line, TumorChloride PeroxidaseEnzyme TherapyMiceMice, Inbred BALB CMixed Function OxygenasesNanospheresTumor MicroenvironmentAntineoplastic AgentsChloride Peroxidaselactate 2-monooxygenaseMixed Function OxygenasesNitric OxideCancer therapyDrug delivery and control releaseEnzyme dynamic therapyImmunotherapyNitric oxide

Identifiers

PMID42243957
PMCPMC13455315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.