Evidence map›Paper›PMID 42243863›Full record

ArticleBMC medicine2026

A large-scale single-nucleus resource reveals a cardiomyocyte-like fibroblast and stage-specific remodeling across cardiomyopathies.

Qianzi Tang, Xingyu Li, Xiongwei Fan, Chenqing Zheng, Huihui Ma, Rong Luo, Yuanling Tang, Shengzhong Liu, Chengming Fan, Yao Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qianzi Tang *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Xingyu Li *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Xiongwei Fan *The Center for Heart Development Hunan Normal University Changsha Hunan Guangdong, Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart Disease, Guangzhou, Guangdong, China.
Chenqing Zheng *Guangdong Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital, Shenzhen, China.
Huihui MaSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Department of Cardiology, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of China, Chengdu, China.
Rong LuoInstitute of Geriatric Cardiovascular Disease, Chengdu Medical College, Chengdu, People's Republic of China.
Yuanling TangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Shengzhong LiuDepartment of Cardiovascular Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chengming FanDepartment of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
Yao ZhangDepartment of Endocrinology, National Clinical Research Center for Child Health and Disorders, Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Children's Hospital of Chongqing Medical University, Ministry of Education, Chongqing, China.
Wanfeng ZhangDepartment of Bioinformatics, College of Artificial Intelligence Medicine, Chongqing Medical University, Chongqing, China.
Xiushan WuThe Center for Heart Development Hunan Normal University Changsha Hunan Guangdong, Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart Disease, Guangzhou, Guangdong, China.
Xiaoping LiSichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Department of Cardiology, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of China, Chengdu, China. lixiaoping@uestc.edu.cn.

Funding

National Natural Science Foundation of China 32171182National Natural Science Foundation of China 81770379Sichuan Provincial Department of Science and Technology - Regional Innovation Cooperation Project No2024YFHZ0214Sichuan Provincial Natural Science Foundation 2024NSFSC0553Sichuan Science and Technology Program 2021ZDZX0008
6 · The paper itself

Abstract

backgroundCardiomyopathies represent a heterogeneous group of myocardial disorders with distinct phenotypes and outcomes, yet their cell-type-specific mechanisms and differences remain incompletely defined.

methodsHere, we present the Cardiac Cell Atlas, a large-scale single-nucleus transcriptomic atlas of 525 cardiac tissue samples (20 newly generated and 505 publicly available) spanning dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), left ventricular non-compaction (LVNC), and non-failing controls, integrating > 2 million nuclei.

resultsThis resource delineates both shared remodeling signatures and divergent trajectories across cardiomyopathies. We identified a previously unrecognized fibroblast (FB) subpopulation expressing cardiomyopathy genes (TNNT2, RYR2, MYBPC3), positioned between fibroblasts and ventricular cardiomyocytes (VCM) and segregating into FB-like (SORBS2

conclusionsTogether, the Cardiac Cell Atlas provides a comprehensive reference for human cardiac cell states and interactions, advancing mechanistic understanding and informing clinical strategies for risk stratification, stage-specific intervention, and improved outcomes in HCM and DCM. The web portal of Cardiac Cell Atlas together with all the datasets are publicly available at http://113.54.15.143:8000/app/index/ .

Indexed as

CardiomyopathiesCell NucleusFibroblastsMyocytes, CardiacHumanscadiac cell atlascardiomyopathyDCMHCMsnRNA-seq

Identifiers

PMID42243863
PMCPMC13465476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.