SynthesisJournal of cardiothoracic surgery2026
A rare case of relapsed primary pulmonary synovial sarcoma (PPSS) following surgery with multidisciplinary team management: case report and systematic review of literature.
Synthesis in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary pulmonary synovial sarcoma (PPSS) is a rare and invasive subtype of soft tissue sarcoma that originates in the lung. Because of its rare incidence, nonspecific presentation, and radiographic overlap with other thoracic malignancies, diagnosis is often delayed. This systematic review aims to synthesize evidence to improve clinical management of such case presentations.
methodsThis systematic review was conducted and reported in accordance with the PRISMA statement, which guided the literature search strategy, data extraction, and data management. To ensure structured and consistent data collection, the PICO framework was applied to define the population, intervention, comparison, and relevant outcomes for each individual reported case of primary pulmonary synovial sarcoma (PPSS). Methodological quality of the included reports was assessed using the Murad tool for case reports and case series. The search targeted single-case reports and case series published through April 2025. In addition, we report a 58-year-old male patient with a confirmed primary pulmonary synovial sarcoma (PPSS). Treatment was provided by a multidisciplinary team (MDT) at the Department of Thoracic Surgery, University Hospital Erlangen.
resultsThe result of our systematic review revealed a total of 146 PPSS cases. Geographical distribution: Asia (56.6%, 82 cases), the Americas (21.4%, 31), Europe (20%, 29), and Africa (2%, 4). The majority of reported patients were male (61.6%, 90), and (29.5%, 43) reported smoking. The surgical resection was performed in (91.1%, 133), chemotherapy in (51.4%, 75), and radiotherapy in (24.0%, 35). Most patients underwent open surgical resection (72.6%), predominantly lobectomy (65.1%), reflecting advanced tumor size at diagnosis, with 80.1% of tumors measuring ≥ 3 cm. The monophasic subtype was the most common (62.3%, 91), followed by the biphasic subtype (22.0%, 32) and the poorly differentiated subtype (15.8%, 23). At the time of publication, the reported patient shows no evidence of disease (NED).
conclusionPPSS requires early diagnosis and multidisciplinary management. Surgical resection is still the most important measure, supplemented by chemotherapy and/or radiotherapy. However, recurrence remains a major challenge. Further research is needed to standardize treatment and improve outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.