Evidence map›Paper›PMID 42243799›Full record

ArticleJournal of nanobiotechnology2026

M2 microglia-derived migrasome-enriched extracellular vesicles restore mitochondrial homeostasis to orchestrate neurovascular unit recovery after ischemic stroke.

Yuanjia Zhang, Jie Wu, Leyi Liu, Yiqian Zhu, Jierui Zhang, Jinghong Xu, Xuefeng Shi, Yu Yu, Chao Wang, Jiajing Xiao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuanjia Zhang *Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Jie Wu *Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
Leyi Liu *Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
Yiqian ZhuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Jierui ZhangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jinghong XuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Xuefeng ShiDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Yu YuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Chao WangDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jiajing XiaoDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Xuanchenye ZhangDepartment of Chemistry, Brandeis University, Waltham, MA, USA.
Zhaorong LiDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Wenqi HuangDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. huangwq@mail.sysu.edu.cn.
Wenzhi LiDepartment of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. wenzhili9@126.com.
Zhongxing WangDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. wzhxing@mail.sysu.edu.cn.
Tingting LiDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. litt95@mail.sysu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515013136National Natural Science Foundation of China 82372187National Natural Science Foundation of China 82402556National Natural Science Foundation of China 82472219
6 · The paper itself

Abstract

Ischemic stroke is a major cause of disability with few treatment options available. Microglia-driven neuroinflammation contributes significantly to stroke pathology, and promoting anti-inflammatory microglial phenotypes represents a promising strategy. Migrasomes are newly discovered organelles mediating intercellular communication, yet their role in ischemic stroke remains unexplored. This study demonstrates that M2 microglia-derived migrasome-enriched extracellular vesicles (EVs) exert potent neuroprotection in both OGD/R cell models and MCAO mice. These migrasome-enriched EVs were efficiently internalized by microglia, astrocytes, neurons, and microvascular endothelial cells, promoting microglial M2 polarization, suppressing astrocytic aberrant activation, reducing neuronal apoptosis, and enhancing angiogenesis. Intracerebral administration of M2 microglia-derived migrasome-enriched EVs significantly reduced infarct volume, ameliorated cerebral edema, improved cerebral blood flow, and accelerated neurological and cognitive recovery without detectable toxicity. Mechanistically, migrasome-enriched EVs activated the cAMP/EPAC1/Rap1 signaling pathway in microglia, leading to restored mitochondrial homeostasis. Collectively, these findings identify M2 microglia-derived migrasome-enriched EVs as novel intercellular messengers that orchestrate neurovascular unit recovery after ischemic stroke, positioning migrasome-enriched EVs as promising candidates for stroke therapy.

Indexed as

Extracellular VesiclesIschemic StrokeMicrogliaMitochondriaAnimalsAstrocytesHomeostasisMaleMiceMice, Inbred C57BLNeuronsSignal TransductionIschemic strokeMicroglia polarizationMigrasome-enriched extracellular vesiclesMitochondrial homeostasisNeurovascular unit recovery

Identifiers

PMID42243799
PMCPMC13455202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.