Evidence map›Paper›PMID 42243733›Full record

Observational studyBMC infectious diseases2026

Temporal trends, antimicrobial non-susceptibility patterns, and clinical predictors of Stenotrophomonas maltophilia in a tertiary care hospital in Palestine: a 7-year retrospective study.

Taqwa Abdeljawad, Wafa ' Sous, Israa Hasan, Nada Janajra, Adham AbuTaha, Ali Sabateen

Abstract readObservational Study
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Observational study in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Taqwa AbdeljawadDepartment of Medical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine. taqwaislam24@gmail.com.
Wafa ' SousDepartment of Medical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.
Israa HasanDepartment of Medical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.
Nada JanajraDepartment of Medical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.
Adham AbuTahaDepartment of Pharmacology, An-Najah National University, Nablus, Palestine.
Ali SabateenDepartment of Infectious Diseases, An-Najah National University Hospital, Nablus, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStenotrophomonas maltophilia is an opportunistic pathogen of increasing clinical importance because of its intrinsic resistance to multiple antimicrobial agents and its growing presence in healthcare environments. However, data describing its epidemiology and antimicrobial susceptibility patterns in Palestine remain limited. This study examined temporal trends, distribution across specimen types and care settings, and antimicrobial resistance profiles of S. maltophilia isolates.

methodsA retrospective observational study was conducted at a tertiary care hospital between 2018 and 2024. Unique clinical isolates of S. maltophilia were identified using the VITEK

resultsA total of 177 unique S. maltophilia isolates were identified, corresponding to a prevalence of 1.08% among all cultures performed. Annual prevalence fluctuated during the study period without evidence of a sustained linear trend. Respiratory specimens accounted for the largest proportion of isolates, and more than one-third originated from intensive care unit (ICU)-related settings. Susceptibility remained highest for cotrimoxazole (80.2%) and levofloxacin (78.5%), whereas ceftazidime showed lower historical non-susceptibility rates (42.9%). Paired analyses demonstrated significantly higher non-susceptibility to ceftazidime than to cotrimoxazole or levofloxacin (p < 0.001). Combined non-susceptibility (non-susceptibility to all three tested agents; CNP) occurred in 5.6% of isolates and was significantly more frequent among ICU-related isolates (21.7% vs. 3.2%, p = 0.004). In multivariable analyses, prior antibiotic exposure (p = 0.044) and COVID-19 infection (p = 0.027) were independently associated with levofloxacin non-susceptibility, whereas invasive medical device use was associated with ceftazidime non-susceptibility (p = 0.004).

conclusionsS. maltophilia isolates demonstrated heterogeneous antimicrobial non-susceptibility patterns, with preserved susceptibility to cotrimoxazole and levofloxacin but reduced activity of ceftazidime. The higher frequency of the combined non-susceptibility phenotype (CNP) among ICU-related isolates suggests that critical care settings may serve as reservoirs for more resistant phenotypes. Continued microbiological surveillance and antimicrobial stewardship are essential to guide empiric therapy and infection-control strategies. CLINICAL

trial registrationNot applicable.

Indexed as

Anti-Bacterial AgentsGram-Negative Bacterial InfectionsStenotrophomonas maltophiliaAdultAgedCeftazidimeDrug Resistance, BacterialDrug Resistance, Multiple, BacterialFemaleHumansLevofloxacinMaleMicrobial Sensitivity TestsMiddle AgedMiddle EastPrevalenceAnti-Bacterial AgentsCeftazidimeLevofloxacinTrimethoprim, Sulfamethoxazole Drug CombinationAntimicrobial resistanceAntimicrobial stewardshipEpidemiologyIntensive care unitPalestineStenotrophomonas maltophiliaSurveillance

Identifiers

PMID42243733
PMCPMC13455391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.