Evidence map›Paper›PMID 42243684›Full record

ArticleBMC genomics2026

Comparative genomic and functional insights into life-cycle plasticity and host adaptation in a wild Nippostrongylus brasiliensis strain from Guangzhou.

Xi Pan, Jinzhi Lu, Chuyue Wang, Yashan Song, Hongyi Li, Muchun Wan, Lihua Xiao, Yaoyu Feng, Dongjuan Yuan

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xi Pan *State Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Jinzhi Lu *State Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Chuyue Wang *State Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yashan SongState Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Hongyi LiState Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Muchun WanState Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Lihua XiaoState Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yaoyu FengState Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. yyfeng@scau.edu.cn.
Dongjuan YuanState Key Laboratory of Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. yuandj@scau.edu.cn.

Funding

111 Center D20008Double First-class Discipline Promotion Project 2023B10564003Guangdong Basic and Applied Basic Research Foundation 2023A1515011964National Natural Science Foundation of China 32473055
6 · The paper itself

Abstract

backgroundNippostrongylus brasiliensis (rat hookworm) is a key model for studying human hookworm infection.

resultsA wild N. brasiliensis isolate from Guangzhou maintains high fecundity for 10 days and persists for 21 days in rats, which is twice as long as reported for reference strains, but survives only 10 to 11 days in mice while causing more severe pathology than that observed in rats. Comparative genomic, transcriptomic, and functional analyses were conducted to explore potential genetic factors associated with these phenotypic differences. Whole-genome sequencing revealed 92.6-93.3% identity to publicly available reference assemblies. Comparative analysis of strain-specific orthogroups identified astacin metalloproteases and four collagens, three being col-117-like genes, that were exclusively expressed in parasitic L4/L5 larvae. Two of these, col-117l12 and col-117l16, were up-regulated in mouse-derived worms compared to rat-derived worms. Lentivirus-mediated RNAi of col-117l16 reduced worm burdens by 77.2%, impaired reproduction, attenuated lesions, and disrupted adult cuticle structure and intestinal positioning.

conclusionsThese findings highlight candidate genes potentially associated with N. brasiliensis life-cycle plasticity and host specificity; however, direct causal attribution of these phenotypic traits to specific genetic factors requires further validation under controlled experimental conditions.

Indexed as

Adaptation, PhysiologicalGenomicsLife Cycle StagesNippostrongylusAnimalsChinaFemaleGene Expression ProfilingMiceRatsStrongylida InfectionsCollagenGenomeHookwormLife cycleNippostrongylus brasiliensis

Identifiers

PMID42243684
PMCPMC13455165

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