ReviewPharmaceutical research2026
Long-Acting Antimalarial Drug Delivery Systems for Chemoprophylaxis: Formulation Strategies and Routes of Administration.
Review in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria chemoprophylaxis generally requires prolonged and frequent administration of antimalarial drugs, which often results in poor patient adherence and reduced prophylactic effectiveness.
objectiveThis review aims to summarize the advancements in long-acting drug delivery systems developed for antimalarial chemoprophylaxis and highlights recent clinical developments in this field.
methodsVarious formulation approaches reported in the literature for sustained antimalarial drug release were reviewed, including oral, parenteral, and topical long-acting delivery systems. Strategies such as gelatin capsules, solid drug nanoparticles, oil-based solutions, implants, polymeric nanorods, lipid-based depot systems, in situ-forming gels, microspheres, and microneedle-based delivery systems were evaluated.
resultsLong-acting antimalarial delivery systems have demonstrated significant potential in minimizing dosing frequency, improving patient adherence, and enhancing prophylactic effectiveness. Various formulation strategies have shown the ability to provide sustained drug release and prolonged protection against malaria.
conclusionLong-acting drug delivery systems represent a promising strategy for improving malaria chemoprophylaxis by overcoming adherence-related challenges associated with conventional dosing regimens. Continued research and clinical advancements in sustained-release antimalarial formulations may significantly contribute to the development of effective antimalarial drug delivery systems for successful chemoprophylactic therapy.
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42243601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.