ArticleMolecular neurobiology2026
Traditional Fermented Multi-Grain Supernatant (Ogi-baba Omidun) Restores Hypothalamic-Pituitary-Testicular Axis Function in a Juvenile Double-Hit PTSD-Neuroinflammation Rat Model.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Juvenile post-traumatic stress disorder (PTSD) compounded by systemic neuroinflammation poses a significant threat to neuroendocrine and reproductive development. This study evaluated the therapeutic potential of a traditional fermented multi-grain supernatant (Ogi-baba Omidun; MGS) and its postbiotics (PSB) in a juvenile rat model of PTSD-neuroinflammation comorbidity induced by single prolonged stress combined with lipopolysaccharide exposure. MGS and PSB significantly ameliorated anxiety-like behaviour and partially restored sexual performance, testicular testosterone, and luteinising hormone levels. Both preparations reduced oxidative stress markers and pro-inflammatory NF-κB signalling and increased anti-inflammatory IL-10 across the hypothalamic-pituitary-testicular axis. Histological and immunofluorescence analyses revealed partial preservation of neuroendocrine cytoarchitecture and attenuation of LC3B-II-associated autophagosome accumulation. These findings indicate that Ogi-baba Omidun exerts multi-target protective effects against the combined impact of traumatic stress and immune activation on the juvenile reproductive axis, supporting its translational potential as an accessible gut-mediated intervention.
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