ArticleEuropean journal of nuclear medicine and molecular imaging2026
Hemispheric lateralization of Tau associations with visual and verbal memory in Alzheimer's disease.
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAlzheimer's disease affects the brain in complex ways, and the location of tau tangles may influence specific types of memory problems. In this study, we examined how tau accumulation relates to verbal and visual memory performance, and whether these associations show a preference for one hemisphere of the brain over the other.
methodsWe administered the Rey Auditory Verbal Learning Test (RAVLT) and its nonverbal analog, the Aggie Figures Learning Test (AFLT), to 132 cognitively unimpaired elderly participants and 44 cognitively impaired, amyloid-positive individuals from the Translational Biomarkers in Aging and Dementia cohort. All participants underwent [18 F]MK6240 tau PET, [18 F]AZD4694 amyloid PET, and structural MRI scans. We analyzed the data using region-of-interest and voxel-wise regression models, as well as correlation analyses.
resultsVoxel-wise analyses showed that higher tau load in the right hemisphere was associated with worse visual memory, confirming a lateralized relationship. Left-hemisphere tau associations with verbal memory were observed at higher t-values. In regression models including both memory scores, visual memory remained significantly associated with tau on the right hemisphere (β
conclusionOur findings support lateralized associations between tau accumulation and memory deficits, with visual memory linked to right-hemisphere tau and verbal memory to left-hemisphere tau. This pattern is consistent with lateralization of memory functions observed in other neurological conditions and highlights the importance of considering hemisphere-specific tau pathology in Alzheimer's disease.
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