Evidence map›Paper›PMID 42243513›Full record

ArticleNPJ precision oncology2026

M.globosa promotes lung cancer progression and M2 macrophage polarization through oxidative phosphorylation.

Junqi Yi, Yiming Zhao, Zhengjiang Li, Anqi Chen, Ziying Tang, Leliang Zheng, Huabo Ge, Qian Yu, Wenliang Liu, Juanjuan Xiang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junqi YiDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yiming ZhaoNHC Key Laboratory of Carcinogenesis and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Zhengjiang LiDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Anqi ChenDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ziying TangDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Leliang ZhengNHC Key Laboratory of Carcinogenesis and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Huabo GeDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qian YuDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wenliang LiuDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Juanjuan XiangNHC Key Laboratory of Carcinogenesis and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan, China. xiangjj@csu.edu.cn.
Jingqun TangDepartment of thoracic surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. tangjq@csu.edu.cn.

Funding

National Natural Science Foundation of China 81972198Postgraduate Innovative Project of Central South University 2025XQLH002the Key Research and Development Program of Hunan 2019SK2253the National Natural Science Foundation of Changsha kq2208299the National Natural Science Foundation of Changsha kq2403084the National Natural Science Foundation of Hunan 2025JJ50173the Natural Science Foundation of Hunan Province 2025JJ50490
6 · The paper itself

Abstract

The lungs are colonized by a variety of microbes which play a significant role in lung cancer progression. In this study, we conducted an in-depth analysis of metagenomic sequencing data obtained from alveolar lavage fluid (ALF) samples of patients with non-small-cell lung cancer (NSCLC) at different clinical stages. The nested qPCR was used to validate the abundance of key fungi and establish a correlation between fungi abundance and patient prognosis. We found that elevated levels of M.globosa correlated with patients at stage1B-3 and worse prognosis. M.globosa enhanced the proliferation of lung cancer cells and promoted tumor growth in vivo by promoting M2-like macrophage polarization, which was primarily driven by oxidative phosphorylation (OXPHOS) activation. The inhibition of OXPHOS in tumor-bearing mice using metformin significantly retarded the tumor growth induced by M. globosa. Together, our clinical observations and experimental findings suggest that intracellular M. globosa infection may contribute to lung cancer progression through immunometabolic remodeling of macrophages.

Identifiers

PMID42243513
PMCPMC13332209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.