Evidence map›Paper›PMID 42243496›Full record

ArticleCommunications biology2026

Comprehensive characterisation of IAA inactivation pathways reveals the impact of glycosylation on auxin metabolism and plant development in Arabidopsis.

Rubén Casanova-Sáez, Aleš Pěnčík, Federica Brunoni, Anita Ament, Pavel Hladík, Asta Žukauskaitė, Jan Šimura, Ute Voß, Ondřej Novák, Malcolm Bennett and 2 more

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rubén Casanova-SáezUmeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden.
Aleš PěnčíkUmeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden.
Federica BrunoniLaboratory of Growth Regulators, Faculty of Science, Palacký University, Olomouc, Czech Republic.ORCID 0000-0003-1497-9419
Anita AmentLaboratory of Growth Regulators, Faculty of Science, Palacký University, Olomouc, Czech Republic.ORCID 0000-0001-5563-7330
Pavel HladíkLaboratory of Growth Regulators, Faculty of Science, Palacký University, Olomouc, Czech Republic.
Asta ŽukauskaitėDepartment of Chemical Biology, Faculty of Science, Palacký University, Olomouc, Czech Republic.
Jan ŠimuraUmeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden.
Ute VoßDivision of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK.
Ondřej NovákLaboratory of Growth Regulators, Faculty of Science, Palacký University, Olomouc, Czech Republic.ORCID 0000-0003-3452-0154
Malcolm BennettDivision of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK.
Karin LjungUmeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden. Karin.ljung@slu.se.ORCID 0000-0003-2901-189X
Eduardo Mateo-BonmatíUmeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden. eduardo.mateo@upm.es.ORCID 0000-0002-2364-5173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alongside biosynthesis and transport, inactivation regulates indole-3-acetic acid (IAA) concentration, a compound with numerous functions in plant development. The main inactive IAA metabolites are oxidised forms and ester- or amide-linked conjugates. DIOXYGENASE FOR AUXIN OXIDATION1 (DAO1) and DAO2, 2-oxoglutarate and iron-dependent dioxygenases, contribute to IAA oxidative inactivation with group II GRETCHEN HAGEN3 (GH3) IAA-amido synthetases, while UDP-glycosyltransferases (UGTs) conjugate IAA to sugars. To study IAA inactivation routes, we generated combinatorial Arabidopsis mutants between all group II GH3s (gh3oct) and DAO1 or DAO2, and between DAOs and the main UGTs. In vivo [

Indexed as

ArabidopsisIndoleacetic AcidsPlant DevelopmentPlant Growth RegulatorsArabidopsis ProteinsGene Expression Regulation, PlantGlycosylationMutationArabidopsis Proteinsindoleacetic acidIndoleacetic AcidsPlant Growth Regulators

Identifiers

PMID42243496
PMCPMC13237164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.