Coronal curvature angle and asymmetrical blood vessel distribution in intervertebral discs from aged cadavers: a pilot study.

Hironobu Uzawa, Hidenobu Miyaso, Yoshiharu Matsuno, Yusuke Nishida, Kyutaro Kawagishi

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Article in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Hironobu UzawaDepartment of Physical Therapy, School of Health Sciences at Narita, International University of Health and Welfare, Kozunomori 4-3, Narita, Chiba, 286-8686, Japan. h.uzawa@med.id.yamagata-u.ac.jp.ORCID http://orcid.org/0000-0001-9168-7917

Hidenobu MiyasoDepartment of Anatomy, School of Medicine, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-Ku, Tokyo, 160-8402, Japan.ORCID http://orcid.org/0000-0003-2212-1500

Yoshiharu MatsunoBasic Medicine Research Centre, International University of Health and Welfare, Kozunomori 4-3, Narita, Chiba, 286-8686, Japan.ORCID http://orcid.org/0000-0002-4277-3269

Yusuke NishidaDepartment of Physical Therapy, School of Health Sciences at Narita, International University of Health and Welfare, Kozunomori 4-3, Narita, Chiba, 286-8686, Japan.

Kyutaro KawagishiDepartment of Anatomy and Structural Science, School of Medicine, Yamagata University, Iidanishi 2-2-2, Yamagata, 990-9585, Japan.ORCID http://orcid.org/0000-0002-8933-3834

Funding

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6 · The paper itself

Abstract

purposeIntervertebral disc degeneration (IVDD) is a major cause of chronic spinal pain and increases with age. Although spinal deformities contribute to asymmetric IVDD, vascular asymmetry within the intervertebral disc (IVD) remains unclear. This study investigated the relationship between differences in vascularity between the concave and convex sides of the IVD and the coronal curvature angle.

methodsThe study comprised two parts: Study A and Study B. Study A included 15 IVDs (C7-T1, T1-T2, and T7-T8; five discs per level) obtained from five cadavers (two females). Study B included 53 IVDs (C7-T1, n = 8; T1-T2, n = 8; T7-T8, n = 8; L1-L2, n = 11; L3-L4, n = 7; and L4-L5, n = 11) from 11 cadavers (seven females). In total, 68 IVDs from 16 cadavers (mean age 84.6 ± 10.0 years) were analyzed. Coronal curvature angles and disc heights were measured. After coronal sectioning, blood vessels were evaluated using hematoxylin and eosin staining in Study A and CD31 immunohistochemistry in Study B.

resultsDisc height was significantly lower on the concave side. In both Study A and Study B, the concave side of the IVD showed increased vascularization. The coronal curvature angle showed a significant association with vascular asymmetry in both studies.

conclusionGreater coronal curvature angles were associated with increased vascular asymmetry within the IVD. However, because of the observational nature of this study, no causal relationship can be inferred. Further experimental studies are needed.

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationAgedAged, 80 and overCadaverFemaleHumansLumbar VertebraeMalePilot ProjectsPlatelet Endothelial Cell Adhesion Molecule-1Thoracic VertebraePlatelet Endothelial Cell Adhesion Molecule-1CadaverCoronal curvatureIntervertebral disc degenerationSpinal deformityVascularization

Identifiers

PMID42243450

DOI10.3390/ijms24010043

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.