Evidence map›Paper›PMID 42243426›Full record

ArticleNeurocritical care2026

Status Epilepticus Is Detected Earlier than Seizures on cEEG in Critically Ill Adults.

Andrea O Rossetti, Cecil D Hahn, Jan Novy, Vincent Alvarez, Kaspar Schindler, Stephan Rüegg, Jong Woo Lee

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03129438 (Impact on Clinical Outcome of Continuous Video-electroencephalography), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03129438 nacompletednot on this map

Impact on Clinical Outcome of Continuous Video-electroencephalography (cEEG) Monitoring in Patients With Disorders of Consciousness: A Randomized Controlled Trial

TypeinterventionalSponsorAndrea Rossetti, MDRan2017 to 2019Enrolled404ConditionsEEG With Periodic Abnormalities, EEG With Abnormally Slow Frequencies, Coma, Outcome, FatalArmscontinuous EEG (cEEG), routine EEG (rEEG)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea O RossettiService de Neurologie, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital, 1011, Lausanne, Switzerland. andrea.rossetti@chuv.ch.ORCID http://orcid.org/0000-0002-7878-172X
Cecil D HahnDivision of Neurology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, Canada.
Jan NovyService de Neurologie, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital, 1011, Lausanne, Switzerland.
Vincent AlvarezService de Neurologie, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and Lausanne University Hospital, 1011, Lausanne, Switzerland.
Kaspar SchindlerSleep-Wake-Epilepsy-Center, Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Stephan RüeggDepartment of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Jong Woo LeeDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030_169379
6 · The paper itself

Abstract

backgroundSeizure burden seems to correlate with clinical outcome in critically ill patients. Continuous electroencephalogram (cEEG) is increasingly utilized in this context but is more resource-demanding than routine EEG (rEEG). Strategies to stratify the risk of seizures on cEEG have been proposed, but the impact of seizure duration on detection latency has not been well characterized.

methodsThis is a retrospective analysis of data from the CERTA trial on critically ill adults (NCT03129438), evaluating detection latencies between recording start and short seizures (events lasting < 5 min) vs. status epilepticus [(SE) ≥ 5 min] on cEEG. Results were correlated to prognosis at 6 months (mortality and functional outcome).

resultsOf 364 patients in the trial, 182 received cEEG. SE was detected in 16 [median latency 0 min, interquartile range (IQR) 0-552] and short seizures in 13 (median latency 375 min, IQR 54-1398; p < 0.030). Patients with seizures/SE had higher mortality (24/29 vs. 65/153, p < 0.001) but comparable functional outcome at 6 months compared with those without seizures/SE.

conclusionsSE events were detected significantly earlier than short seizures. If confirmed in larger cohorts, and supported by additional data on the relationship between timely seizures/SE detection, treatment and outcome, these findings may aid in optimizing EEG resource allocation.

Indexed as

Continuous EEGOutcomePrognosisSeizure burden

Identifiers

PMID42243426

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Registered trials

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