One-pot click synthesis of hybrid triazole-pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays.

In the present work, we describe an efficient, straightforward, and environmentally friendly method for synthesizing hybrid triazole-pyridine-functionalized polyphenol derivatives via a one-pot, three-component click reaction under ultrasound irradiation. The reactions are high-yielding (65-90%), require shorter reaction times, use lower solvent volumes, show notable acceleration, and involve lower energy consumption. Taking into account the 12 principles of green chemistry and the above considerations, the one-pot, three-component click reactions under US irradiation may be considered environmentally friendly. The green character of our one-pot three-component click reaction setup procedure under US irradiation is also confirmed by the green chemistry metrics Atom Economy, Environmental factor, and Process Mass Intensity, which have meaningful values in accord with the green chemistry principles. A notable influence of the halogen atom in the click reactions was observed; bromine derivatives are much more suitable for one-pot, three-component click reactions under US irradiation, with a fourfold yield increase. The preliminary antimicrobial assay reveals that some of the hybrid triazole-pyridine-functionalized polyphenol derivatives exhibit very good activity against Gram-positive bacteria (in the nanograms/mL range) and good activity against Gram-negative bacteria and fungi (in the micrograms/mL range).