Evidence map›Paper›PMID 42243342›Full record

ArticleCellular and molecular life sciences : CMLS2026

Multi-omics profiling reveals EMT-driven fibroblast activation in the renal injury niche.

Songmei Zhai, Keru Li, Kaidong Liu, Tianyi Ren, Chen Lv, Qizhe Sun, Jiayi Sun, Yuan Zhang, Wenyuan Zhao, Tianyu Li

Abstract read
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In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Songmei Zhai *Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Keru Li *Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Kaidong Liu *Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Tianyi RenDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Chen LvDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Qizhe SunDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Jiayi SunDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Yuan ZhangDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China.
Wenyuan ZhaoDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150000, China. zhaowenyuan@ems.hrbmu.edu.cn.ORCID http://orcid.org/0000-0002-6477-9434
Tianyu LiState Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, 150000, China. lity@hrbmu.edu.cn.

Funding

National Natural Science Foundation of China 32370716National Natural Science Foundation of China 82470413
6 · The paper itself

Abstract

Persistent renal injury creates conditions for activating fibroblasts. However, due to the complexity of the renal injury microenvironment, the mechanisms driving fibroblast activation remain poorly understood. Here, we use single-nucleus RNA sequencing data and spatial transcriptomic data to investigate the mechanisms of fibroblast activation in renal injury. By integrating 619,137 single-cell nuclei from 80 samples, we identify 10 fibroblast subtypes within the renal injury environment. The FIB

Indexed as

Acute Kidney InjuryEpithelial-Mesenchymal TransitionFibroblastsKidneyAnimalsExtracellular MatrixGene Expression ProfilingHumansMultiomicsSignal TransductionSOXC Transcription FactorsSpatial TranscriptomicsTranscriptomeSOXC Transcription FactorsEpithelial-mesenchymal transition (EMT)FibroblastRenal injuryRenal structureSOX4

Identifiers

PMID42243342
PMCPMC13457812

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.