Evidence map›Paper›PMID 42243334›Full record

ArticleArchives of virology2026

In vitro efficacy of anti-influenza active compounds against clinical isolates with high growth capability.

Waldy Yudha Perdana, Akeno Tsuneki-Tokunaga, Koyuki Atifa Rahmi, Alfredo A Hinay, Kyosuke Kanai, Seiji Kageyama

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Waldy Yudha PerdanaDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.ORCID http://orcid.org/0009-0008-6041-2409
Akeno Tsuneki-TokunagaDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Koyuki Atifa RahmiDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.ORCID http://orcid.org/0000-0003-4871-4259
Alfredo A HinayDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.ORCID http://orcid.org/0000-0003-4761-1514
Kyosuke KanaiDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.ORCID http://orcid.org/0000-0002-7984-207X
Seiji KageyamaDivision of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan. skageyama@tottori-u.ac.jp.ORCID http://orcid.org/0000-0002-5220-6137

Funding

JSPS KAKENHI 23K09670JSPS KAKENHI 23K19481
6 · The paper itself

Abstract

Highly replicative influenza viruses have been linked to elevated nasopharyngeal viral load in patients, while in murine model these viruses are associated with amplified cytokine responses, and greater severity. In the present study, five anti-influenza agents-including four neuraminidase inhibitors (zanamivir, laninamivir, peramivir, and oseltamivir acid) and one polymerase acidic endonuclease inhibitor (baloxavir acid)-were evaluated against both a laboratory strain (PR8) and four clinical isolates lacking known resistance mutations. Madin-Darby Canine Kidney (MDCK) and A549 human lung epithelial cells were inoculated at 1x10

Indexed as

Antiviral AgentsInfluenza A virusInfluenza, HumanA549 CellsAcids, CarbocyclicAnimalsCell LineDibenzothiepinsDogsGuanidinesHumansMadin Darby Canine Kidney CellsMorpholinesNeuraminidaseOseltamivirOxazinesAcids, CarbocyclicAntiviral AgentsbaloxavirDibenzothiepinsGuanidineslaninamivirMorpholinesNeuraminidaseOseltamivirOxazinesperamivirPurine NucleosidesPyransPyridonesRibonucleosidesSialic AcidsTriazinesZanamivir

Identifiers

PMID42243334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.