ArticleThe Journal of antibiotics2026
Inhibition of the SOS response by olivetol improves the efficacy of DNA-damaging antibiotics in Escherichia coli.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is known that the rapid increase in antibiotic-resistant bacteria is reducing the effectiveness of existing antibiotics. The spread of resistant Escherichia coli strains has become a major concern in public health. Developing compounds that increase antibiotic activity is a promising alternative strategy to overcome this problem. SOS response mechanism in bacteria activates DNA repair and increases antibiotic resistance. Natural sources, such as lichens, are valuable for discovering potential SOS inhibitors due to their unique secondary metabolites with medicinal potential. This study aims to enhance the efficacy of antibiotics in E. coli by inhibiting SOS with olivetol, a natural metabolite derived from lichens. The SOS inhibition potential of olivetol was quantitatively assessed using qRT-PCR and GFP-based monitor strains. Moreover, MIC values of DNA damage-inducing ciprofloxacin, trimethoprim, nitrofurantoin and mitomycin C antibiotics were reassessed following combined treatment with olivetol. Overall, the results show that olivetol effectively suppresses the SOS response at high concentrations and reduces the MIC values of the antibiotics trimethoprim, nitrofurantoin, and mitomycin C. These findings indicate that olivetol has significant potential as a natural SOS inhibitor that can enhance the performances of certain antibiotics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.