ArticleScientific reports2026
A TriNetX global collaborative network retrospective cohort study on the impact of COVID-19 vaccination on juvenile idiopathic arthritis.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective is to determine the Impact of COVID-19 Vaccination and Medical Utilization in Juvenile Idiopathic Arthritis (JIA) patients. Our study retrieved data from the US Collaborative Network in TriNetX between January 1st, 2020, and June 30th, 2023. We investigated the incidence of COVID-19, medical utilization, and mortality in JIA patients. The HR and 95% CI of the outcomes were calculated between propensity score-matched (PSM) 1:1. 652 vaccinated and 652 unvaccinated JIA patients were enrolled. The vaccinated group demonstrated a significantly elevated risk of infection of COVID-19 but also a notably higher overall use of medical services, with a hazard ratio (HR) of 2.112 and a 95% confidence interval (C.I.) ranging from 1.081 to 4.129. No significant difference in the risk of outcomes comparing the COVID-19 vaccine group and the influenza vaccine group. During the Delta variant, vaccination was associated with a statistically non-significant rise in COVID-19 risk (HR = 1.402, 95% C.I.= 0.599-28.60). In the era of Omicron there was an increased rate of overall medical service use (HR = 2.326, 95% C.I.= 0.884-6.121). JIA patients were found to have higher risk of SARS-CoV-2 infection when vaccinated against COVID-19 compared to those who didn't in this database study, keeping in mind confounders inherent to observational data and selection bias that may limit this conclusion, and could also be affected by different COVID-19 variants. Increased medical resource use was found in these patients but there was no significant rise in mortality, warranting further investigation into the vaccine's impact on protection in JIA patients and immunological responses involved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.